التفاصيل البيبلوغرافية
| العنوان: |
Coassociations between IL10 polymorphisms, IL-10 production, helminth infection, and asthma/wheeze in an urban tropical population in Brazil ; Journal of Allergy and Clinical Immunology |
| المؤلفون: |
Figueiredo, Camila Alexandrina, Barreto, Mauricio Lima, Alcântara-Neves, Neuza Maria, Rodrigues, Laura Cunha, Cooper, Philip John, Cruz Filho, Álvaro Augusto Souza da, Carvalho, Lain Carlos Pontes de, Lemaire, Denise Carneiro, Costa, Ryan dos Santos, Amorim, Leila Denise Alves Ferreira, Vergara, Candelaria, Rafaels, Nicholas M., Gao, Li, Foster, Cassandra, Campbell, Monica, Mathias, Rasika A., Barnes, Kathleen C. |
| المصدر: |
http://www.sciencedirect.com/science/article/pii/S0091674912017642. |
| بيانات النشر: |
Journal of Allergy and Clinical Immunology |
| سنة النشر: |
2013 |
| مصطلحات موضوعية: |
IL10, Polymorphisms, Helminth infection, Immune modulation, Allergy, Asthma, Social Changes Asthma, Allergy in Latin America |
| الوصف: |
p. 1683–1690 ; Background Helminth infections are associated with protection against allergies. It is postulated that IL-10 production after helminth infection suppresses skin hypersensitivity and increases IgG4 production, protecting against allergies. Objective We aimed to determine whether IL10 polymorphisms are associated with helminth infection and the risk of wheeze and allergy. Methods Twelve IL10 single nucleotide polymorphisms were genotyped in 1353 children aged 4 to 11 years living in a poor urban area in Salvador, Brazil. Wheezing status, Ascaris lumbricoides and Trichuris trichiura infection, IL-10 production by peripheral blood leukocytes stimulated with A lumbricoides extract, serum total IgE levels, specific IgE levels, skin prick test responses to common aeroallergens, and IgG4 and IgE anti–A lumbricoides antibody levels were measured in all children. Association tests were performed by using logistic or linear regression when appropriate, including sex, age, helminth infection, and principal components for ancestry informative markers as covariates by using PLINK. Results Allele G of marker rs3024496 was associated with the decreased production of IL-10 by peripheral blood leukocytes in response to A lumbricoides stimulation. Allele C of marker rs3024498 was negatively associated with helminth infection or its markers. Marker rs3024492 was positively associated with the risk of atopic wheeze, total IgE levels, and skin prick test responses to cockroach. Conclusions Our findings suggest that IL10 polymorphisms might play a role in the production of IL-10, helminth infection, and allergy. We hypothesize that polymorphisms related to protection against helminths, which would offer an evolutionary advantage to subjects in the past, might be associated with increased risk of allergic diseases. ; Salvador |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
http://repositorio.ufba.br/ri/handle/ri/13559; v. 131, n. 6 |
| الاتاحة: |
http://repositorio.ufba.br/ri/handle/ri/13559 |
| Rights: |
Acesso Aberto |
| رقم الانضمام: |
edsbas.7025AAB7 |
| قاعدة البيانات: |
BASE |