Academic Journal
Evaluation of cellular response and drug delivery efficacy of nanoporous stainless steel material
| العنوان: | Evaluation of cellular response and drug delivery efficacy of nanoporous stainless steel material |
|---|---|
| المؤلفون: | Inho Bae, Kyung-Seob Lim, Jun-Kyu Park, Ju Han Song, Sin-Hye Oh, Jung-Woo Kim, Zijiao Zhang, Chan Park, Jeong-Tae Koh |
| المصدر: | Biomaterials Research, Vol 25, Iss 1, Pp 1-8 (2021) |
| بيانات النشر: | American Association for the Advancement of Science (AAAS) |
| سنة النشر: | 2021 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Nanoporous structure, Stainless steel, Surface modification, Cellular response, Drug delivery, Medical technology, R855-855.5 |
| الوصف: | Objective Various surface modification techniques that can further improve the function and usability of stainless steel as a medical device have been reported. In the present study, the physical and biological properties of nanoporous stainless steel as well as its usefulness for drug delivery were assessed. Methods The specimen was prepared with a circular disk shape (15 mm in diameter and 1 mm in thickness). The disk was subjected to electropolishing at a constant voltage of 20 V and 10 A for 10 min in an acidic environment (50% H2SO4). Everolimus (EVL) was used as a testing drug for drug-loading capacity of the material surface and release kinetics. The physiobiological properties of the material were assessed using platelet adhesion, and smooth muscle cell (SMC) adhesion, migration, and proliferation assays. Results The surface roughness of the postpolishing group was greater than that of the nonpolishing group. Platelet adhesion and SMC adhesion and migration were inhibited in the postpolishing group compared to those in the prepolishing group. In the postpolishing group, the total amount of EVL on the surface (i.e., drug storage rate) was higher and the drug release rate was lower, with half the amount of the EVL released within 4 days compared with only 1 day for that of the prepolishing group. Conclusion Taken together, this stainless steel with a nanoporous surface could be used as a medical device for controlling cellular responses and carrying drugs. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2055-7124 |
| Relation: | https://doi.org/10.1186/s40824-021-00232-8; https://doaj.org/toc/2055-7124; https://doaj.org/article/5611bd066df243498e376d56eb08c66b |
| DOI: | 10.1186/s40824-021-00232-8 |
| الاتاحة: | https://doi.org/10.1186/s40824-021-00232-8 https://doaj.org/article/5611bd066df243498e376d56eb08c66b |
| رقم الانضمام: | edsbas.7020B472 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20557124 |
|---|---|
| DOI: | 10.1186/s40824-021-00232-8 |