التفاصيل البيبلوغرافية
| العنوان: |
Real-World Clinical Outcomes of Neoadjuvant Platinum-Based Chemotherapy with Nivolumab in Non-Small Cell Lung Cancer |
| المؤلفون: |
Walid Shalata, Sameh Daher, Natali Maimon Rabinovitch, Sivan Shamai, Waleed Kian, Ilit Turgeman, Yulia Dudnik, Olga Kazareen, Yulia Rovitsky, Edmond Sabo, Dan Levy Faber, Ronen Galili, Ory Wiesel, Konstantin Baranovsky, Abed Agbarya |
| المصدر: |
Journal of Clinical Medicine ; Volume 13 ; Issue 21 ; Pages: 6568 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2024 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
neoadjuvant, chemotherapy, immunotherapy, non-small cell lung cancer, resection surgery, real-world clinical outcomes |
| الوصف: |
Background: Lung cancer is among the most prevalent and serious forms of cancer, characterized by an allogenic phenotype that presents significant therapeutic challenges. Materials and Methods: We analyzed medical records from January 2022 to August 2023, focusing on individuals aged 18 and older diagnosed with resectable NSCLC who received neoadjuvant chemo-immunotherapy prior to surgical intervention. Results: The cohort comprised 56 patients, predominantly smokers (95%) and male (74%), with 80% presenting the disease at stage III. Of the participants, 44 underwent surgery, with 95% receiving lobar resection. Clinical assessments via PET-CT imaging revealed an 86% rate of response or disease stabilization, while pathological evaluations showed complete and major pathological responses in 61% of cases. Conclusions: This real-world data supports the safety and efficacy of incorporating immune checkpoint inhibitors in the neoadjuvant treatment of NSCLC, followed by surgical resection. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Pulmonology; https://dx.doi.org/10.3390/jcm13216568 |
| DOI: |
10.3390/jcm13216568 |
| الاتاحة: |
https://doi.org/10.3390/jcm13216568 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.6F60DE5 |
| قاعدة البيانات: |
BASE |