Academic Journal
Comparative molecular genomic analyses of a spontaneous rhesus macaque model of mismatch repair-deficient colorectal cancer.
| العنوان: | Comparative molecular genomic analyses of a spontaneous rhesus macaque model of mismatch repair-deficient colorectal cancer. |
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| المؤلفون: | Nejla Ozirmak Lermi, Stanton B Gray, Charles M Bowen, Laura Reyes-Uribe, Beth K Dray, Nan Deng, R Alan Harris, Muthuswamy Raveendran, Fernando Benavides, Carolyn L Hodo, Melissa W Taggart, Karen Colbert Maresso, Krishna M Sinha, Jeffrey Rogers, Eduardo Vilar |
| المصدر: | PLoS Genetics, Vol 18, Iss 4, p e1010163 (2022) |
| بيانات النشر: | Public Library of Science (PLoS) |
| سنة النشر: | 2022 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Genetics, QH426-470 |
| الوصف: | Colorectal cancer (CRC) remains the third most common cancer in the US with 15% of cases displaying Microsatellite Instability (MSI) secondary to Lynch Syndrome (LS) or somatic hypermethylation of the MLH1 promoter. A cohort of rhesus macaques from our institution developed spontaneous mismatch repair deficient (MMRd) CRC with a notable fraction harboring a pathogenic germline mutation in MLH1 (c.1029C |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1553-7390 1553-7404 |
| Relation: | https://doi.org/10.1371/journal.pgen.1010163; https://doaj.org/toc/1553-7390; https://doaj.org/toc/1553-7404; https://doaj.org/article/3345afdd7e5447958a5094fe6c001467 |
| DOI: | 10.1371/journal.pgen.1010163 |
| الاتاحة: | https://doi.org/10.1371/journal.pgen.1010163 https://doaj.org/article/3345afdd7e5447958a5094fe6c001467 |
| رقم الانضمام: | edsbas.6F59282C |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 15537390 15537404 |
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| DOI: | 10.1371/journal.pgen.1010163 |