Academic Journal
Biological variation of inflammatory and iron metabolism markers in high-endurance recreational athletes:are these markers useful for athlete monitoring?
| العنوان: | Biological variation of inflammatory and iron metabolism markers in high-endurance recreational athletes:are these markers useful for athlete monitoring? |
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| المؤلفون: | Diaz-Garzon, Jorge, Itkonen, Outi, Aarsand, Aasne K, Sandberg, Sverre, Coskun, Abdurrahman, Carobene, Anna, Jonker, Niels, Bartlett, William A, Buño, Antonio, Fernandez-Calle, Pilar |
| المصدر: | Diaz-Garzon , J , Itkonen , O , Aarsand , A K , Sandberg , S , Coskun , A , Carobene , A , Jonker , N , Bartlett , W A , Buño , A & Fernandez-Calle , P 2024 , ' Biological variation of inflammatory and iron metabolism markers in high-endurance recreational athletes : are these markers useful for athlete monitoring? ' , Clinical Chemistry and Laboratory Medicine , vol. 62 , no. 5 , pp. 844-852 . https://doi.org/10.1515/cclm-2023-1071 |
| سنة النشر: | 2024 |
| المجموعة: | Discovery - University of Dundee Online Publications |
| مصطلحات موضوعية: | athletes, biological variation, erythropoietin, hepcidin, soluble transferrin receptor, /dk/atira/pure/subjectarea/asjc/2700/2704, name=Biochemistry, medical, /dk/atira/pure/subjectarea/asjc/1300/1308, name=Clinical Biochemistry |
| الوصف: | OBJECTIVES: To deliver biological variation (BV) data for serum hepcidin, soluble transferrin receptor (sTfR), erythropoietin (EPO) and interleukin 6 (IL-6) in a population of well-characterized high-endurance athletes, and to evaluate the potential influence of exercise and health-related factors on the BV. METHODS: Thirty triathletes (15 females) were sampled monthly (11 months). All samples were analyzed in duplicate and BV estimates were delivered by Bayesian and ANOVA methods. A linear mixed model was applied to study the effect of factors related to exercise, health, and sampling intervals on the BV estimates. RESULTS: Within-subject BV estimates (CVI) were for hepcidin 51.9 % (95 % credibility interval 46.9-58.1), sTfR 10.3 % (8.8-12) and EPO 27.3 % (24.8-30.3). The mean concentrations were significantly different between sex, but CVI estimates were similar and not influenced by exercise, health-related factors, or sampling intervals. The data were homogeneously distributed for EPO but not for hepcidin or sTfR. IL-6 results were mostly below the limit of detection. Factors related to exercise, health, and sampling intervals did not influence the BV estimates. CONCLUSIONS: This study provides, for the first time, BV data for EPO, derived from a cohort of well-characterized endurance athletes and indicates that EPO is a good candidate for athlete follow-up. The application of the Bayesian method to deliver BV data illustrates that for hepcidin and sTfR, BV data are heterogeneously distributed and using a mean BV estimate may not be appropriate when using BV data for laboratory and clinical applications. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1515/cclm-2023-1071 |
| الاتاحة: | https://discovery.dundee.ac.uk/en/publications/dd749da5-6f2f-4a65-b338-b236d975badf https://doi.org/10.1515/cclm-2023-1071 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.6F3A55C1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1515/cclm-2023-1071 |
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