Academic Journal
Pharmacokinetic behavior of marbofloxacin after intravenous and intramuscular administrations in adult goats
| العنوان: | Pharmacokinetic behavior of marbofloxacin after intravenous and intramuscular administrations in adult goats |
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| المؤلفون: | Waxman, S., Rodríguez, C., González, F., De Vicente, M. L., San Andrés, M. I., San Andrés, M. D. |
| المصدر: | Journal of Veterinary Pharmacology and Therapeutics ; volume 24, issue 6, page 375-378 ; ISSN 0140-7783 1365-2885 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2001 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | The pharmacokinetic behavior of marbofloxacin was studied in goats after single‐dose intravenous (i.v.) and intramuscular (i.m.) administrations of 2 mg/kg bodyweight. Drug concentration in plasma was determined by high performance liquid chromatography (HPLC) and the data collected were subjected to compartmental and noncompartmental kinetic analysis. This compound presented a relatively high volume of distribution ( V ss =1.31 L/kg), which suggests good tissue penetration, and a total body clearance ( Cl ) of 0.23 L/kg·h, which is related to a long elimination half‐life ( t 1/2 β =7.18 h and 6.70 h i.v. and i.m., respectively). Pharmacokinetic parameters were not significantly different between both routes of administration. Marbofloxacin was rapidly absorbed after i.m. administration ( T max =0.9 h) and had high bioavailability ( F =100.74%). |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1046/j.1365-2885.2001.00357.x |
| الاتاحة: | http://dx.doi.org/10.1046/j.1365-2885.2001.00357.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1046%2Fj.1365-2885.2001.00357.x https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1365-2885.2001.00357.x |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.6F1220EC |
| قاعدة البيانات: | BASE |
| DOI: | 10.1046/j.1365-2885.2001.00357.x |
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