Academic Journal
A phase 2 trial investigating the efficacy and safety of the mPGES-1 inhibitor vipoglanstat in systemic sclerosis-related Raynaud's
| العنوان: | A phase 2 trial investigating the efficacy and safety of the mPGES-1 inhibitor vipoglanstat in systemic sclerosis-related Raynaud's |
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| المؤلفون: | Tornling, Göran, Edenius, Charlotte, Pauling, John D, Denton, Christopher P, Olsson, Anna, Kowalski, Jan, Murray, Andrea, Anderson, Marina, Bhat, Smita, Del Galdo, Francesco, Hall, Frances, Korkosz, Mariusz, Krasowska, Dorota, Olas, Jacek, Smith, Vanessa, van Laar, Jacob M, Vonk, Madelon C, Wojteczek, Anna, Herrick, Ariane L |
| المصدر: | Tornling , G , Edenius , C , Pauling , J D , Denton , C P , Olsson , A , Kowalski , J , Murray , A , Anderson , M , Bhat , S , Del Galdo , F , Hall , F , Korkosz , M , Krasowska , D , Olas , J , Smith , V , van Laar , J M , Vonk , M C , Wojteczek , A & Herrick , A L 2024 , ' A phase 2 trial investigating the efficacy and safety of the mPGES-1 inhibitor vipoglanstat .... |
| سنة النشر: | 2024 |
| المجموعة: | The University of Manchester: Research Explorer - Publications |
| مصطلحات موضوعية: | clinical trial, microsomal prostaglandin E synthase-1, vipoglanstat, Raynaud’s phenomenon, systemic sclerosis |
| الوصف: | OBJECTIVE: Our objective was to test the hypothesis, in a double-blind, placebo-controlled study that vipoglanstat, an inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1) which decreases prostaglandin E2 (PGE2) and increases prostacyclin biosynthesis, improves RP. METHODS: Patients with systemic sclerosis (SSc) and ≥7 RP attacks during the last screening week prior to a baseline visit were randomised to four weeks treatment with vipoglanstat 120 mg or placebo. A daily electronic diary captured RP attacks (duration and pain) and Raynaud's Condition Score, with change in RP attacks/week as primary end point. Cold challenge assessments were performed at baseline and end of treatment. Exploratory endpoints included patients' and physicians' global impression of change, Assessment of Scleroderma-associated Raynaud's Phenomenon questionnaire, mPGES-1 activity, and urinary excretion of arachidonic acid metabolites. RESULTS: Sixty-nine subjects received vipoglanstat (n = 33) or placebo (n = 36). Mean weekly number of RP attacks (baseline; vipoglanstat 14.4[SD 6.7], placebo 18.2[12.6]) decreased by 3.4[95% CI -5.8;-1.0] and 4.2[-6.5;-2.0] attacks per week (p= 0.628) respectively. All patient reported outcomes improved, with no difference between the groups. Mean change in recovery of peripheral blood flow after cold challenge did not differ between the study groups. Vipoglanstat fully inhibited mPGES-1, resulting in 57% reduction of PGE2 and 50% increase of prostacyclin metabolites in urine. Vipoglanstat was safe and well tolerated. CONCLUSION: Although vipoglanstat was safe, and well tolerated in a dose achieving full inhibition of mPGES-1, it was ineffective in SSc-related RP. Further development and evaluation of vipoglanstat will therefore be in other diseases where mPGES-1 plays a pathogenetic role. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://research.manchester.ac.uk/en/publications/74d749cc-203e-409c-b79c-e47c857ec147 |
| DOI: | 10.1093/rheumatology/keae049 |
| الاتاحة: | https://research.manchester.ac.uk/en/publications/74d749cc-203e-409c-b79c-e47c857ec147 https://doi.org/10.1093/rheumatology/keae049 https://www.mendeley.com/catalogue/8633e9e7-dfb9-3234-98bf-f73ba5737b81/ |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.6EA179F5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/rheumatology/keae049 |
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