Academic Journal
Plasma levels of multiple cardiovascular- and inflammation-related proteins analysed for associations with disease activity and anti-cyclic citrullinated peptide status in active early rheumatoid arthritis
| العنوان: | Plasma levels of multiple cardiovascular- and inflammation-related proteins analysed for associations with disease activity and anti-cyclic citrullinated peptide status in active early rheumatoid arthritis |
|---|---|
| المؤلفون: | Mašić, D., Stengaard-Pedersen, K., Løgstrup, B. Bridal, Hørslev-Petersen, K., Hetland, M. L., Junker, P., Østergaard, M., Nielsen, C. H., Kruhøffer, M., Bøgebjerg, M. E., Röttger, R., Christensen, R., Ellingsen, T. |
| المصدر: | Mašić , D , Stengaard-Pedersen , K , Løgstrup , B B , Hørslev-Petersen , K , Hetland , M L , Junker , P , Østergaard , M , Nielsen , C H , Kruhøffer , M , Bøgebjerg , M E , Röttger , R , Christensen , R & Ellingsen , T 2023 , ' Plasma levels of multiple cardiovascular- and inflammation-related proteins analysed for associations with disease activity and anti-cyclic citrullinated peptide status in active early rheumatoid arthritis ' , Clinical and Experimental Rheumatology , vol. 41 , no. 9 , pp. 1801-1807 . https://doi.org/10.55563/clinexprheumatol/hrjqdm |
| سنة النشر: | 2023 |
| المجموعة: | University of Copenhagen: Research / Forskning ved Københavns Universitet |
| مصطلحات موضوعية: | biomarkers, cluster analyses, rheumatoid arthritis |
| الوصف: | Objective To compare plasma levels of 92 cardiovascular- and inflammation-related proteins (CIRPs) and to analyse for associations with anti-cyclic citrullinated peptide (anti-CCP) status and disease activity in early and treatment-naive rheumatoid arthritis (RA). Methods Olink CVD-III-panel was used to measure 92 CIRP plasma levels in 180 early, treatment-naive, and highly inflamed RA patients from the OPERA trial. CIRP plasma levels as well as correlation between CIRP plasma levels and RA disease activity were compared between anti-CCP groups. CIRP level-based hierarchical cluster analysis was performed in each anti-CCP group separately. Results The study included 117 anti-CCP-positive and 63 anti-CCP-negative RA patients. Among the 92 CIRPs measured, the levels of chitotriosidase-1 (CHIT1) and tyrosine-protein-phosphatase non-receptor-type substrate-1 (SHPS-1) were increased and those of metalloproteinase inhibitor-4 (TIMP-4) decreased in the anti-CCP-negative group compared to anti-CCP-positive group. The strongest associations with RA disease activity were found for interleukin-2 receptor-subunit-alpha (IL2-RA) and E-selectin levels in the anti-CCP-negative group and for C-C-motif chemokine-16 levels (CCL16) in the anti-CCP-positive group. None of the differences passed the Hochberg sequential multiplicity test, however, the CIPRs were interacting and thus the prerequisites of the Hochberg procedure were not fulfilled. CIRP level-based cluster analysis identified two patient clusters in both anti-CCP groups. Demographic and clinical characteristics were similar in the two clusters for each anti-CCP group. Conclusion In active and early RA, the findings regarding CHIT1, SHPS-1 TIMP-4, IL2-RA, E-selectin, and CCL16 differed between the two anti-CCP groups. In addition, we identified two patient clusters that were independent of the anti-CCP status. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.55563/clinexprheumatol/hrjqdm |
| الاتاحة: | https://researchprofiles.ku.dk/da/publications/plasma-levels-of-multiple-cardiovascular-and-inflammationrelated-proteins-analysed-for-associations-with-disease-activity-and-anticyclic-citrullinated-peptide-status-in-active-early-rheumatoid-arthritis(8d726cea-3b36-4de9-9148-66fef291f296).html https://doi.org/10.55563/clinexprheumatol/hrjqdm |
| Rights: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.6E7529FE |
| قاعدة البيانات: | BASE |
| ResultId |
1 |
|---|---|
| Header |
edsbas BASE edsbas.6E7529FE 891 3 Academic Journal academicJournal 890.976379394531 |
| PLink |
https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsbas&AN=edsbas.6E7529FE&custid=s6537998&authtype=sso |
| FullText |
Array
(
[Availability] => 0
)
Array ( [0] => Array ( [Url] => https://researchprofiles.ku.dk/da/publications/plasma-levels-of-multiple-cardiovascular-and-inflammationrelated-proteins-analysed-for-associations-with-disease-activity-and-anticyclic-citrullinated-peptide-status-in-active-early-rheumatoid-arthritis(8d726cea-3b36-4de9-9148-66fef291f296).html# [Name] => EDS - BASE [Category] => fullText [Text] => View record in BASE [MouseOverText] => View record in BASE ) ) |
| Items |
Array
(
[Name] => Title
[Label] => Title
[Group] => Ti
[Data] => Plasma levels of multiple cardiovascular- and inflammation-related proteins analysed for associations with disease activity and anti-cyclic citrullinated peptide status in active early rheumatoid arthritis
)
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Mašić%2C+D%2E%22">Mašić, D.</searchLink><br /><searchLink fieldCode="AR" term="%22Stengaard-Pedersen%2C+K%2E%22">Stengaard-Pedersen, K.</searchLink><br /><searchLink fieldCode="AR" term="%22Løgstrup%2C+B%2E+Bridal%22">Løgstrup, B. Bridal</searchLink><br /><searchLink fieldCode="AR" term="%22Hørslev-Petersen%2C+K%2E%22">Hørslev-Petersen, K.</searchLink><br /><searchLink fieldCode="AR" term="%22Hetland%2C+M%2E+L%2E%22">Hetland, M. L.</searchLink><br /><searchLink fieldCode="AR" term="%22Junker%2C+P%2E%22">Junker, P.</searchLink><br /><searchLink fieldCode="AR" term="%22Østergaard%2C+M%2E%22">Østergaard, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Nielsen%2C+C%2E+H%2E%22">Nielsen, C. H.</searchLink><br /><searchLink fieldCode="AR" term="%22Kruhøffer%2C+M%2E%22">Kruhøffer, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Bøgebjerg%2C+M%2E+E%2E%22">Bøgebjerg, M. E.</searchLink><br /><searchLink fieldCode="AR" term="%22Röttger%2C+R%2E%22">Röttger, R.</searchLink><br /><searchLink fieldCode="AR" term="%22Christensen%2C+R%2E%22">Christensen, R.</searchLink><br /><searchLink fieldCode="AR" term="%22Ellingsen%2C+T%2E%22">Ellingsen, T.</searchLink> ) Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => Mašić , D , Stengaard-Pedersen , K , Løgstrup , B B , Hørslev-Petersen , K , Hetland , M L , Junker , P , Østergaard , M , Nielsen , C H , Kruhøffer , M , Bøgebjerg , M E , Röttger , R , Christensen , R & Ellingsen , T 2023 , ' Plasma levels of multiple cardiovascular- and inflammation-related proteins analysed for associations with disease activity and anti-cyclic citrullinated peptide status in active early rheumatoid arthritis ' , Clinical and Experimental Rheumatology , vol. 41 , no. 9 , pp. 1801-1807 . https://doi.org/10.55563/clinexprheumatol/hrjqdm ) Array ( [Name] => DatePubCY [Label] => Publication Year [Group] => Date [Data] => 2023 ) Array ( [Name] => Subset [Label] => Collection [Group] => HoldingsInfo [Data] => University of Copenhagen: Research / Forskning ved Københavns Universitet ) Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%22biomarkers%22">biomarkers</searchLink><br /><searchLink fieldCode="DE" term="%22cluster+analyses%22">cluster analyses</searchLink><br /><searchLink fieldCode="DE" term="%22rheumatoid+arthritis%22">rheumatoid arthritis</searchLink> ) Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => Objective To compare plasma levels of 92 cardiovascular- and inflammation-related proteins (CIRPs) and to analyse for associations with anti-cyclic citrullinated peptide (anti-CCP) status and disease activity in early and treatment-naive rheumatoid arthritis (RA). Methods Olink CVD-III-panel was used to measure 92 CIRP plasma levels in 180 early, treatment-naive, and highly inflamed RA patients from the OPERA trial. CIRP plasma levels as well as correlation between CIRP plasma levels and RA disease activity were compared between anti-CCP groups. CIRP level-based hierarchical cluster analysis was performed in each anti-CCP group separately. Results The study included 117 anti-CCP-positive and 63 anti-CCP-negative RA patients. Among the 92 CIRPs measured, the levels of chitotriosidase-1 (CHIT1) and tyrosine-protein-phosphatase non-receptor-type substrate-1 (SHPS-1) were increased and those of metalloproteinase inhibitor-4 (TIMP-4) decreased in the anti-CCP-negative group compared to anti-CCP-positive group. The strongest associations with RA disease activity were found for interleukin-2 receptor-subunit-alpha (IL2-RA) and E-selectin levels in the anti-CCP-negative group and for C-C-motif chemokine-16 levels (CCL16) in the anti-CCP-positive group. None of the differences passed the Hochberg sequential multiplicity test, however, the CIPRs were interacting and thus the prerequisites of the Hochberg procedure were not fulfilled. CIRP level-based cluster analysis identified two patient clusters in both anti-CCP groups. Demographic and clinical characteristics were similar in the two clusters for each anti-CCP group. Conclusion In active and early RA, the findings regarding CHIT1, SHPS-1 TIMP-4, IL2-RA, E-selectin, and CCL16 differed between the two anti-CCP groups. In addition, we identified two patient clusters that were independent of the anti-CCP status. ) Array ( [Name] => TypeDocument [Label] => Document Type [Group] => TypDoc [Data] => article in journal/newspaper ) Array ( [Name] => Language [Label] => Language [Group] => Lang [Data] => English ) Array ( [Name] => DOI [Label] => DOI [Group] => ID [Data] => 10.55563/clinexprheumatol/hrjqdm ) Array ( [Name] => URL [Label] => Availability [Group] => URL [Data] => https://researchprofiles.ku.dk/da/publications/plasma-levels-of-multiple-cardiovascular-and-inflammationrelated-proteins-analysed-for-associations-with-disease-activity-and-anticyclic-citrullinated-peptide-status-in-active-early-rheumatoid-arthritis(8d726cea-3b36-4de9-9148-66fef291f296).html<br />https://doi.org/10.55563/clinexprheumatol/hrjqdm ) Array ( [Name] => Copyright [Label] => Rights [Group] => Cpyrght [Data] => info:eu-repo/semantics/closedAccess ) Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edsbas.6E7529FE ) |
| RecordInfo |
Array
(
[BibEntity] => Array
(
[Identifiers] => Array
(
[0] => Array
(
[Type] => doi
[Value] => 10.55563/clinexprheumatol/hrjqdm
)
)
[Languages] => Array
(
[0] => Array
(
[Text] => English
)
)
[Subjects] => Array
(
[0] => Array
(
[SubjectFull] => biomarkers
[Type] => general
)
[1] => Array
(
[SubjectFull] => cluster analyses
[Type] => general
)
[2] => Array
(
[SubjectFull] => rheumatoid arthritis
[Type] => general
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Plasma levels of multiple cardiovascular- and inflammation-related proteins analysed for associations with disease activity and anti-cyclic citrullinated peptide status in active early rheumatoid arthritis
[Type] => main
)
)
)
[BibRelationships] => Array
(
[HasContributorRelationships] => Array
(
[0] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Mašić, D.
)
)
)
[1] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Stengaard-Pedersen, K.
)
)
)
[2] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Løgstrup, B. Bridal
)
)
)
[3] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Hørslev-Petersen, K.
)
)
)
[4] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Hetland, M. L.
)
)
)
[5] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Junker, P.
)
)
)
[6] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Østergaard, M.
)
)
)
[7] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Nielsen, C. H.
)
)
)
[8] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Kruhøffer, M.
)
)
)
[9] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Bøgebjerg, M. E.
)
)
)
[10] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Röttger, R.
)
)
)
[11] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Christensen, R.
)
)
)
[12] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Ellingsen, T.
)
)
)
)
[IsPartOfRelationships] => Array
(
[0] => Array
(
[BibEntity] => Array
(
[Dates] => Array
(
[0] => Array
(
[D] => 01
[M] => 01
[Type] => published
[Y] => 2023
)
)
[Identifiers] => Array
(
[0] => Array
(
[Type] => issn-locals
[Value] => edsbas
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => $2
[Type] => main
)
)
)
)
)
)
)
|
| IllustrationInfo |