Academic Journal
Plasma levels of multiple cardiovascular- and inflammation-related proteins analysed for associations with disease activity and anti-cyclic citrullinated peptide status in active early rheumatoid arthritis
| العنوان: | Plasma levels of multiple cardiovascular- and inflammation-related proteins analysed for associations with disease activity and anti-cyclic citrullinated peptide status in active early rheumatoid arthritis |
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| المؤلفون: | Mašić, D., Stengaard-Pedersen, K., Løgstrup, B. Bridal, Hørslev-Petersen, K., Hetland, M. L., Junker, P., Østergaard, M., Nielsen, C. H., Kruhøffer, M., Bøgebjerg, M. E., Röttger, R., Christensen, R., Ellingsen, T. |
| المصدر: | Mašić , D , Stengaard-Pedersen , K , Løgstrup , B B , Hørslev-Petersen , K , Hetland , M L , Junker , P , Østergaard , M , Nielsen , C H , Kruhøffer , M , Bøgebjerg , M E , Röttger , R , Christensen , R & Ellingsen , T 2023 , ' Plasma levels of multiple cardiovascular- and inflammation-related proteins analysed for associations with disease activity and anti-cyclic citrullinated peptide status in active early rheumatoid arthritis ' , Clinical and Experimental Rheumatology , vol. 41 , no. 9 , pp. 1801-1807 . https://doi.org/10.55563/clinexprheumatol/hrjqdm |
| سنة النشر: | 2023 |
| المجموعة: | University of Copenhagen: Research / Forskning ved Københavns Universitet |
| مصطلحات موضوعية: | biomarkers, cluster analyses, rheumatoid arthritis |
| الوصف: | Objective To compare plasma levels of 92 cardiovascular- and inflammation-related proteins (CIRPs) and to analyse for associations with anti-cyclic citrullinated peptide (anti-CCP) status and disease activity in early and treatment-naive rheumatoid arthritis (RA). Methods Olink CVD-III-panel was used to measure 92 CIRP plasma levels in 180 early, treatment-naive, and highly inflamed RA patients from the OPERA trial. CIRP plasma levels as well as correlation between CIRP plasma levels and RA disease activity were compared between anti-CCP groups. CIRP level-based hierarchical cluster analysis was performed in each anti-CCP group separately. Results The study included 117 anti-CCP-positive and 63 anti-CCP-negative RA patients. Among the 92 CIRPs measured, the levels of chitotriosidase-1 (CHIT1) and tyrosine-protein-phosphatase non-receptor-type substrate-1 (SHPS-1) were increased and those of metalloproteinase inhibitor-4 (TIMP-4) decreased in the anti-CCP-negative group compared to anti-CCP-positive group. The strongest associations with RA disease activity were found for interleukin-2 receptor-subunit-alpha (IL2-RA) and E-selectin levels in the anti-CCP-negative group and for C-C-motif chemokine-16 levels (CCL16) in the anti-CCP-positive group. None of the differences passed the Hochberg sequential multiplicity test, however, the CIPRs were interacting and thus the prerequisites of the Hochberg procedure were not fulfilled. CIRP level-based cluster analysis identified two patient clusters in both anti-CCP groups. Demographic and clinical characteristics were similar in the two clusters for each anti-CCP group. Conclusion In active and early RA, the findings regarding CHIT1, SHPS-1 TIMP-4, IL2-RA, E-selectin, and CCL16 differed between the two anti-CCP groups. In addition, we identified two patient clusters that were independent of the anti-CCP status. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.55563/clinexprheumatol/hrjqdm |
| الاتاحة: | https://researchprofiles.ku.dk/da/publications/plasma-levels-of-multiple-cardiovascular-and-inflammationrelated-proteins-analysed-for-associations-with-disease-activity-and-anticyclic-citrullinated-peptide-status-in-active-early-rheumatoid-arthritis(8d726cea-3b36-4de9-9148-66fef291f296).html https://doi.org/10.55563/clinexprheumatol/hrjqdm |
| Rights: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.6E7529FE |
| قاعدة البيانات: | BASE |
| DOI: | 10.55563/clinexprheumatol/hrjqdm |
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