Academic Journal
Heavy‐Atom‐Modulated Supramolecular Assembly Increases Antitumor Potency against Malignant Breast Tumors via Tunable Cooperativity
| العنوان: | Heavy‐Atom‐Modulated Supramolecular Assembly Increases Antitumor Potency against Malignant Breast Tumors via Tunable Cooperativity |
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| المؤلفون: | Guo, Zhengqing, He, Hui, Zhang, Yi, Rao, Jiaming, Yang, Tao, Li, Ting, Wang, Lu, Shi, Mengke, Wang, Mengya, Qiu, Shihong, Song, Xue, Ke, Hengte, Chen, Huabing |
| المساهمون: | National Basic Research Program of China, National Natural Science Foundation of China, Priority Academic Program Development of Jiangsu Higher Education Institutions |
| المصدر: | Advanced Materials ; volume 33, issue 2 ; ISSN 0935-9648 1521-4095 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2020 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Triple‐negative breast cancer (TNBC) remains with highest incidence and mortality rates among females, and a critical bottleneck lies in rationally establishing potent therapeutics against TNBC. Here, the self‐assembled micellar nanoarchitecture of heavy‐atom‐modulated supramolecules with efficient cytoplasmic translocation and tunable photoconversion is shown, for potent suppression against primary, metastatic, and recurrent TNBC. Multi‐iodinated boron dipyrromethene micelles yield tunable photoconversion into singlet oxygen and a thermal effect, together with deep penetration and subsequent cytoplasmic translocation at the tumor. Tetra‐iodinated boron dipyrromethene micelles (4‐IBMs) particularly show a distinctly enhanced cooperativity of antitumor efficiency through considerable expressions of apoptotic proteins, potently suppressing subcutaneous, and orthotopic TNBC models, together with reduced oxygen dependence. Furthermore, 4‐IBMs yield preferable anti‐metastatic and anti‐recurrent efficacies through the inhibition of metastasis‐relevant proteins, distinct immunogenic cell death, and re‐education of M2 macrophages into tumoricidal M1 phenotype as compared to chemotherapy and surgical resection. These results offer insights into the cooperativity of supramolecular nanoarchitectures for potent phototherapy against TNBC. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/adma.202004225 |
| الاتاحة: | https://doi.org/10.1002/adma.202004225 https://onlinelibrary.wiley.com/doi/pdf/10.1002/adma.202004225 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/adma.202004225 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.6E431DCF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/adma.202004225 |
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