Academic Journal
A Metastatic Intrahepatic Cholangiocarcinoma With HPCs Features: Report of a Case
| العنوان: | A Metastatic Intrahepatic Cholangiocarcinoma With HPCs Features: Report of a Case |
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| المؤلفون: | Fu, Qiang, Liu, Pan, Jin, Shangkun, Zhang, Xu, Liu, Chuanjiang, Hu, Mingxing, Wang, Yuzhu, Zhang, Hongwei, Qin, Tao |
| المساهمون: | National Natural Science Foundation of China |
| المصدر: | Frontiers in Oncology ; volume 12 ; ISSN 2234-943X |
| بيانات النشر: | Frontiers Media SA |
| سنة النشر: | 2022 |
| المجموعة: | Frontiers (Publisher - via CrossRef) |
| الوصف: | Intrahepatic cholangiocarcinoma (ICC) is a highly lethal hepatobiliary neoplasm, which originates from the bile ducts proximal to the second-order division. ICC can be anatomically divided into two subtypes: the large duct type (mucin-production ICC, muc-ICC) and the small duct type (mixed-ICC) origins from hepatic progenitor cells (HPCs). The immunoreactivity of S100P and neural cell adhesion molecule (NCAM) are useful biomarkers to distinguish the two subtypes. In this study, we report a difficult-to-diagnose case of metastatic retroperitoneal tumor of occult hepatolithiasis-associated ICC. Besides, this case was both positive for S100P and NCAM, considered as a rare muc-ICC with the HPCs features. Tumor whole exome sequencing detection results by Genetron (China) revealed that there were 41 gene mutations in this patient. The SMAD4-p.His530ThrfsTer47 and KRAS-p.Gly12Val mutation might promote the occurrence and distant metastasis of the tumor. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| DOI: | 10.3389/fonc.2022.829235 |
| DOI: | 10.3389/fonc.2022.829235/full |
| الاتاحة: | http://dx.doi.org/10.3389/fonc.2022.829235 https://www.frontiersin.org/articles/10.3389/fonc.2022.829235/full |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.6E126147 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fonc.2022.829235 |
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