Academic Journal
Progress Towards an OECD Reporting Framework for Transcriptomics and Metabolomics in Regulatory Toxicology
| العنوان: | Progress Towards an OECD Reporting Framework for Transcriptomics and Metabolomics in Regulatory Toxicology |
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| المؤلفون: | Harrill, Joshua, Viant, Mark, Yauk, Carole, Sachana, Magdalini, Gant, Timothy, Auerbach, Scott, Beger, Richard, Bouhifd, Mounir, O’brien, Jason, Burgoon, Lyle, Caiment, Florian, Carpi, Donatella, Chen, Tao, Chorley, Brian, Colbourne, John, Corvi, Raffaella, Debrauwer, Laurent, O’donovan, Claire, Ebbels, Timothy.M.D., Ekman, Drew, Faulhammer, Frank, Gribaldo, Laura, Hilton, Gina, Jones, Stephanie, Kende, Aniko, Lawson, Thomas, Leite, Sofia, Leonards, Pim E.G., Luijten, Mirjam, Martin, Alberto, Moussa, Laura, Rudaz, Serge, Schmitz, Oliver, Sobanski, Tomasz, Strauss, Volker, Vaccari, Monica, Vijay, Vikrant, Weber, Ralf J.M., Williams, Antony, Williams, Andrew, Thomas, Russell, Whelan, Maurice |
| المساهمون: | US Environmental Protection Agency (EPA), University of Birmingham Birmingham, University of Ottawa Ottawa, Organisation de Coopération et de Développement Economiques = Organisation for Economic Co-operation and Development (OCDE), Centre for Radiation, Chemical and Environmental Hazards, Public Health England London, National Institute of Environmental Health Sciences Durham, NC, USA (NIEHS-NIH), National Institutes of Health Bethesda, MD, USA (NIH), National Center for Toxicological Research, Partenaires INRAE, European Chemicals Agency (ECHA), Maastricht University Maastricht, US Army Engineer Research and Development Center, European Commission - Joint Research Centre Ispra (JRC), Metatoul AXIOM (E20), MetaboHUB-MetaToul, MetaboHUB-Génopole Toulouse Midi-Pyrénées Auzeville (GENOTOUL), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-MetaboHUB-Génopole Toulouse Midi-Pyrénées Auzeville (GENOTOUL), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-ToxAlim (ToxAlim), Université de Toulouse (UT)-Ecole d'Ingénieurs de Purpan (INP - PURPAN), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Ecole d'Ingénieurs de Purpan (INP - PURPAN), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), ToxAlim (ToxAlim), European Bioinformatics Institute Hinxton (EMBL-EBI), EMBL Heidelberg, Imperial College London, BASF SE, Syngenta, Jealott’s Hill International Research Centre, Vrije Universiteit Amsterdam Amsterdam (VU), National Institute for Public Health and the Environment Bilthoven (RIVM), Center for Veterinary Medicine, U.S. Food and Drug Administration (FDA), Université de Genève = University of Geneva (UNIGE), Public Health Agency of Canada, Environment Protection Authority Victoria (EPA), TWG was supported by the National Institutes of Health Research under the Environmental Exposures and Health Protection Research Unit co-led from Imperial College London and Public Health England (https://eeh.hpru.nihr.ac.uk/) . ML was supported by the Dutch Ministry of Health, Welfare and Support. This work was supported in part by a European Chemicals Agency contract to Michabo Health Science (ECHA/2018/135) and by the European Chemical Industry Council (Cefic, awarded to BASF, Imperial College London, Syngenta, University of Birmingham and Vrije Universiteit Amsterdam) ., ANR-11-INBS-0010,METABOHUB,Développement d'une infrastructure française distribuée pour la métabolomique dédiée à l'innovation(2011) |
| المصدر: | ISSN: 0273-2300. |
| بيانات النشر: | CCSD Elsevier |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | MRF, OECD, QA/QC, TRF, metabolomics, metabolomics reporting framework, regulatory, toxicology, transcriptomics, transcriptomics reporting framework, [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; Omics methodologies are widely used in toxicological research to understand modes and mechanisms of toxicity. Increasingly, these methodologies are being applied to questions of regulatory interest such as molecular point-of-departure derivation and chemical grouping/read-across. Despite its value, widespread regulatory acceptance of omics data has not yet occurred. Barriers to the routine application of omics data in regulatory decision making have been: 1) lack of transparency for data processing methods used to convert raw data into an interpretable list of observations; and 2) lack of standardization in reporting to ensure that omics data, associated metadata and the methodologies used to generate results are available for review by stakeholders, including regulators. Thus, in 2017, the Organisation for Economic Co-operation and Development (OECD) Extended Advisory Group on Molecular Screening and Toxicogenomics (EAGMST) launched a project to develop guidance for the reporting of omics data aimed at fostering further regulatory use. Here, we report on the ongoing development of the first formal reporting framework describing the processing and analysis of both transcriptomic and metabolomic data for regulatory toxicology. We introduce the modular structure, content, harmonization and strategy for trialling this reporting framework prior to its publication by the OECD. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| ردمك: | 978-0-00-691627-7 0-00-691627-9 |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/34333066; PUBMED: 34333066; PUBMEDCENTRAL: PMC8808338; WOS: 000691627900005 |
| DOI: | 10.1016/j.yrtph.2021.105020 |
| الاتاحة: | https://hal.inrae.fr/hal-03313213 https://hal.inrae.fr/hal-03313213v1/document https://hal.inrae.fr/hal-03313213v1/file/main.pdf https://doi.org/10.1016/j.yrtph.2021.105020 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.6E01B982 |
| قاعدة البيانات: | BASE |
| ردمك: | 9780006916277 0006916279 |
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| DOI: | 10.1016/j.yrtph.2021.105020 |