Academic Journal
A mathematical framework for the emergence of winners and losers in cell competition
| العنوان: | A mathematical framework for the emergence of winners and losers in cell competition |
|---|---|
| المؤلفون: | Pak, TF, Pitt-Francis, J, Baker, RE |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2024 |
| المجموعة: | Oxford University Research Archive (ORA) |
| الوصف: | Cell competition is a process in multicellular organisms where cells interact with their neighbours to determine a "winner" or "loser" status. The loser cells are eliminated through programmed cell death, leaving only the winner cells to populate the tissue. Cell competition is context-dependent; the same cell type can win or lose depending on the cell type it is competing against. Hence, winner/loser status is an emergent property. A key question in cell competition is: how do cells acquire their winner/loser status? In this paper, we propose a mathematical framework for studying the emergence of winner/loser status based on a set of quantitative criteria that distinguishes competitive from non-competitive outcomes. We apply this framework in a cell-based modelling context, to both highlight the crucial role of active cell death in cell competition and identify the factors that drive cell competition. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://ora.ox.ac.uk/objects/uuid:5fd00cba-9284-4675-bc0e-329b5d3b5b2a; https://doi.org/10.1016/j.jtbi.2023.111666 |
| DOI: | 10.1016/j.jtbi.2023.111666 |
| الاتاحة: | https://doi.org/10.1016/j.jtbi.2023.111666 https://ora.ox.ac.uk/objects/uuid:5fd00cba-9284-4675-bc0e-329b5d3b5b2a |
| Rights: | info:eu-repo/semantics/openAccess ; CC Attribution (CC BY) |
| رقم الانضمام: | edsbas.6DED0CFE |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.jtbi.2023.111666 |
|---|