Academic Journal
Prognostic value of preoperative inflammatory ratios in early glottic cancer treated with transoral laser surgery
| العنوان: | Prognostic value of preoperative inflammatory ratios in early glottic cancer treated with transoral laser surgery |
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| المؤلفون: | Juesas Iglesias, Luis, Sánchez‐Canteli, Mario, Pedregal Mallo, Daniel, Otero‐Rosales, María, López, Fernando, García‐Pedrero, Juana M., Rodrigo, Juan P. |
| المساهمون: | Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Cáncer, European Commission, Universidad de Oviedo |
| المصدر: | Head & Neck ; volume 46, issue 4, page 819-830 ; ISSN 1043-3074 1097-0347 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2024 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Background There is growing evidence regarding the prognostic utility of ratios such as neutrophil‐to‐lymphocyte ratio (NLR), platelet‐to‐lymphocyte ratio (PLR), and systemic immune‐inflammatory index (SIII) in head and neck squamous cell carcinoma (HNSCC). However, most studies to date include heterogeneous series with different treatments or tumor subsites. Methods We collected data from 201 patients with stage I–II glottic squamous cell carcinoma treated with transoral laser surgery. NLR, PLR, and SIII were calculated from preoperative cell blood count, cut‐off points were obtained by ROC curve analysis, and survival rates were calculated. Results High NLR ( p = 0.012) and SIII ( p = 0.037), but not PLR ( p = 0.48), were associated with worse disease‐specific survival (DSS). A similar trend was observed with overall survival (OS), although it did not reach statistical significance. On multivariable analyses, both high NLR (HR = 3.8, 95% CI = 1.5–9.9, p = 0.006) and high SIII (HR = 2.77, 95% CI = 1.1–6.9, p = 0.03) were significantly associated with shortened DSS. Conclusions Preoperative NLR and SIII emerge as independent prognostic biomarkers for early‐stage surgically treated glottic tumors and could guide individualized follow‐up. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/hed.27631 |
| الاتاحة: | http://dx.doi.org/10.1002/hed.27631 https://onlinelibrary.wiley.com/doi/pdf/10.1002/hed.27631 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.6DE6FB80 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/hed.27631 |
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