Academic Journal
Neuroprotective effects of preischemia subcutaneous magnesium sulfate in transient cerebral ischemia
| العنوان: | Neuroprotective effects of preischemia subcutaneous magnesium sulfate in transient cerebral ischemia |
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| المؤلفون: | Åžirin, Bekir Hayrettin, Yılık, Levent, Ortaç, Ragıp, Åžirin, Hadiye, CoÅŸkun, Erdal, Tetik, Cihat |
| سنة النشر: | 1998 |
| المجموعة: | Pamukkale University Repository / Pamukkale Üniversitesi Açık Erişim Arşivi |
| مصطلحات موضوعية: | Cerebral protection, Animals, Cerebral ischemia, Magnesium, Rat, Somatosensory evoked potentials, magnesium sulfate, animal experiment, animal model, animal tissue, article, brain ischemia, controlled study, drug efficacy, evoked somatosensory response, histopathology, neuroprotection, nonhuman, priority journal, reperfusion, subcutaneous drug administration, treatment outcome, Calcium Channel Blockers, Disease Models, Animal, Evaluation Studies, Evoked Potentials, Somatosensory, Heart Arrest, Induced |
| الوصف: | Objective: Neurological injury due to transient cerebral ischemia is a potential complication of cardiovascular surgery. The neuroprotective effect of magnesium, when given subcutaneously before the ischemia, was assessed in a rat model of transient global cerebral ischemia. Methods: Thirty-six male Wistar albino rats were included to this randomized, controlled, prospective study. In 24 animals, ischemia was induced with four-vessel occlusion technique with the duration of 15 min. MgSO4 was given 600 mg/kg subcutaneously 48 h before the procedure in group 1 (n = 12). Similar volume of saline solution was used in animals of control group (group 2, n = 12). The animals in group 3 (sham group, n = 12) were anesthetized and subjected to operative dissections without vascular occlusion. Physiological parameters and somatosensory evoked-potentials (SEP) were monitored in animals before ischemia, during ischemia and in the first 30 min of reperfusion. Their neurological outcome had been clinically evaluated and scored up to 4 days postischemia. The intergroup differences were compared. Then the animals were sacrificed and their brains were processed for histopathological examination. Results: In group 3, SEP amplitudes did not change during the procedures, and all animals recovered without neurologic deficits. At the end of ischemic period, the average amplitude was reduced to 5 ± 3% of the baseline in all ischemic animals. This was followed by a gradual return to 87 ± 10% and 83 ± 8% of the initial amplitude after 30 min of reperfusion in group 1 and group 2, respectively (P ;gt; 0.05). The average neurological score was significantly higher in group 1 than in group 2 at 48, 72 and 96 h after the ischemic insult (P ;lt; 0.05). Histological observations were clearly correlated with the neurological findings. Conclusion: The results suggest that subcutaneous MgSO4 reduces cerebral injury and preserves neurologic function when given two days before the transient global ischemia in rats. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | European Journal of Cardio-thoracic Surgery; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/11499/5646; 14; 82; 88; 9726620; WOS:000075422200024 |
| DOI: | 10.1016/S1010-7940(98)00140-7 |
| الاتاحة: | https://hdl.handle.net/11499/5646 https://doi.org/10.1016/S1010-7940(98)00140-7 |
| Rights: | open |
| رقم الانضمام: | edsbas.6DD55407 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/S1010-7940(98)00140-7 |
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