التفاصيل البيبلوغرافية
| العنوان: |
Synthesis of hydroxy benzoin/benzil analogs and investigation of their antioxidant, antimicrobial, enzyme inhibition, and cytotoxic activities |
| المؤلفون: |
Yayli, Nurettin, Kilic, Gozde, Celik, Gonca, Kahriman, Nuran, Kanbolat, Seyda, Bozdeveci, Arif, Karaoglu, Sengul Alpay, Aliyazicioglu, Rezzan, Sellitepe, Hasan Erdinc, Dogan, Inci Selin, Aydin, Ali |
| المصدر: |
TURKISH JOURNAL OF CHEMISTRY 45(3) 788-804 |
| سنة النشر: |
2021 |
| الوصف: |
In this study, hydroxy benzoin (1-7), benzil (8-14), and benzoin/benzil-O-beta-D-glucosides (15-25) were synthesized to investigate their biological activities. An efficient method for synthesizing hydroxy benzoin compounds (1-7) was prepared from four different benzaldehydes using an ultrasonic bath. Then, antioxidant (FRAP, CUPRAC, and DPPH), antimicrobial (3 Gram (-), 4/6 Gram (+), one tuberculosis and one fungus), and enzyme inhibition (acetylcholinesterase, butyrylcholine esterase, tyrosinase, alpha-amylase, and alpha- glucosidase) for the all synthesized compounds (1-25) were evaluated. And also, four most active compounds (4, 12, 18a+b, and 25) from each group were evaluated to the human cervical cancer cell line (HeLa) and anticancer screening tests against the human retinal normal cell line (RPE). Compound 4 showed HeLa and RPE cancer cell activities as much as cisplatin. The synthesized compounds were characterized by spectroscopic methods (NMR, FT-IR, UV, LC-QTOF-MS) and the ACD NMR program's help. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| Relation: |
https://aperta.ulakbim.gov.tr/record/229812; oai:aperta.ulakbim.gov.tr:229812 |
| الاتاحة: |
https://aperta.ulakbim.gov.tr/record/229812 |
| Rights: |
info:eu-repo/semantics/openAccess ; http://www.opendefinition.org/licenses/cc-by |
| رقم الانضمام: |
edsbas.6DC314E2 |
| قاعدة البيانات: |
BASE |