Academic Journal
Genome-wide mapping of genetic determinants influencing DNA methylation and gene expression in human hippocampus
| العنوان: | Genome-wide mapping of genetic determinants influencing DNA methylation and gene expression in human hippocampus |
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| المؤلفون: | Schulz, H., Ruppert, A., Herms, S., Wolf, C., Mirza-Schreiber, N., Stegle, O., Czamara, D., Forstner, A., Sivalingam, S., Schoch, S., Moebus, S., Pütz, B., Hillmer, A., Fricker, N., Vatter, H., Müller-Myhsok, B., Noethen, M., Becker, A., Hoffmann, P., Sander, T., Cichon, S. |
| المصدر: | NATURE COMMUNICATIONS |
| سنة النشر: | 2017 |
| المجموعة: | Max Planck Society: MPG.PuRe |
| الوصف: | Emerging evidence emphasizes the strong impact of regulatory genomic elements in neurodevelopmental processes and the complex pathways of brain disorders. The present genome-wide quantitative trait loci analyses explore the cis-regulatory effects of single-nucleotide polymorphisms (SNPs) on DNA methylation (meQTL) and gene expression (eQTL) in 110 human hippocampal biopsies. We identify cis-meQTLs at 14,118 CpG methylation sites and cis-eQTLs for 302 3'-mRNA transcripts of 288 genes. Hippocampal cis-meQTL-CpGs are enriched in flanking regions of active promoters, CpG island shores, binding sites of the transcription factor CTCF and brain eQTLs. Cis-acting SNPs of hippocampal meQTLs and eQTLs significantly overlap schizophrenia-associated SNPs. Correlations of CpG methylation and RNA expression are found for 34 genes. Our comprehensive maps of cis-acting hippocampal meQTLs and eQTLs provide a link between disease-associated SNPs and the regulatory genome that will improve the functional interpretation of non-coding genetic variants in the molecular genetic dissection of brain disorders. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | http://hdl.handle.net/21.11116/0000-0001-9F4A-A; http://hdl.handle.net/21.11116/0000-0001-9F4C-8 |
| الاتاحة: | http://hdl.handle.net/21.11116/0000-0001-9F4A-A http://hdl.handle.net/21.11116/0000-0001-9F4C-8 |
| Rights: | info:eu-repo/semantics/openAccess ; https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.6D8638F9 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |