Academic Journal
Incidental coronary artery calcification on non-gated CT thorax correlates with risk of cardiovascular events and death.
| العنوان: | Incidental coronary artery calcification on non-gated CT thorax correlates with risk of cardiovascular events and death. |
|---|---|
| المؤلفون: | Wetscherek, Maria TA, McNaughton, Edwina, Majcher, Veronika, Wetscherek, Andreas, Sadler, Timothy J, Alsinbili, Ahmed, Teh, Wen Hui, Moore, Samuel D, Patel, Nirav, Smith, William PW, Krishnan, Unni |
| المصدر: | essn: 1432-1084 ; nlmid: 9114774 |
| بيانات النشر: | Springer Science and Business Media LLC //dx.doi.org/10.1007/s00330-023-09428-z Eur Radiol |
| سنة النشر: | 2023 |
| المجموعة: | Apollo - University of Cambridge Repository |
| مصطلحات موضوعية: | Computed tomography, Coronary artery calcification, Preventative cardiology, Humans, Adult, Middle Aged, Aged, Retrospective Studies, Coronary Vessels, Brain Ischemia, Coronary Angiography, Risk Factors, Risk Assessment, Stroke, Coronary Artery Disease, Tomography, X-Ray Computed, Thorax, Vascular Calcification, Prognosis |
| الوصف: | OBJECTIVES: To assess coronary artery calcification (CAC) on non-contrast non-ECG-gated CT thorax (NC-NECG-CTT) and to evaluate its correlation with short-term risk of cardiovascular disease (CVD) events and death. METHODS: Single-institution retrospective study including all patients 40-70 years old who underwent NC-NECG-CTT over a period of 6 months. Individuals with known CVD were excluded. The presence of CAC was assessed and quantified by the Agatston score (CACS). CAC severity was defined as mild (< 100), moderate (100-400), or severe (> 400). CVD events (including CVD death, myocardial infarction, revascularisation procedures, ischaemic stroke, acute peripheral atherosclerotic ischaemia), and all-cause mortality over a median of 3.5 years were recorded. Cox proportional-hazards regression modelling was performed including CACS, age, gender and CVD risk factors (smoking, hypertension, diabetes mellitus, dyslipidaemia, and family history of CVD). RESULTS: Of the total 717 eligible cases, 325 (45%) had CAC. In patients without CAC, there was only one CVD event, compared to 26 CVD events including 5 deaths in patients with CAC. The presence and severity of CAC correlated with CVD events (p < 0.001). A CACS > 100 was significantly associated with both CVD events, hazard ratio (HR) 5.74, 95% confidence interval: 2.19-15.02; p < 0.001, and all-cause mortality, HR 1.7, 95% CI: 1.08-2.66; p = 0.02. Ever-smokers with CAC had a significantly higher risk for all-cause mortality compared to never-smokers (p = 0.03), but smoking status was not an independent predictor for CVD events in any subgroup category of CAC severity. CONCLUSIONS: The presence and severity of CAC assessed on NC-NECG-CTT correlates with short-term cardiovascular events and death. KEY POINTS: • Patients aged 40-70 years old without known CVD but with CAC on NC-NECG-CTT have a higher risk of CVD events compared to those without CAC. • CAC (Agatston) score above 100 confers a 5.7-fold increase in the risk of short-term CVD events in ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | https://www.repository.cam.ac.uk/handle/1810/346915 |
| DOI: | 10.17863/CAM.94332 |
| الاتاحة: | https://www.repository.cam.ac.uk/handle/1810/346915 https://doi.org/10.17863/CAM.94332 |
| رقم الانضمام: | edsbas.6D72BE34 |
| قاعدة البيانات: | BASE |
| DOI: | 10.17863/CAM.94332 |
|---|