Academic Journal
Plant-produced human growth hormone shows biological activity in a rat model
| العنوان: | Plant-produced human growth hormone shows biological activity in a rat model |
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| المؤلفون: | Rabindran, S., Stevenson, N., Roy, G., Fedorkin, O., Skarjinskaia, M., Ensley, B., Yusibov, V. |
| سنة النشر: | 2009 |
| المجموعة: | Publikationsdatenbank der Fraunhofer-Gesellschaft |
| Time: | 540, 571, 572, 660 |
| الوصف: | S.530-534 ; Plants have been shown to be efficient systems for expressing a wide range of recombinant proteins from various origins. Here, using a plant virus-based expression vector to produce human growth hormone (hGH) in Nicotiana benthamiana plants, we demonstrate, for the first time, that the plant-produced hGH (pphGH) is biologically active in a hypophysectomized rat model. We observed an average weight gain of similar to 17 g per animal in a group of 10 animals that were injected subcutaneously with pphGH with 60 mu g/dose for 10 days. With the increasing demand for hGH, accompanied with the need to make this recombinant protein available to a wider population at a more reasonable cost, plants provide a feasible alternative to current production platforms. ; 25 ; Nr.2 |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | Biotechnology progress; https://publica.fraunhofer.de/handle/publica/218562 |
| DOI: | 10.1002/btpr.130 |
| الاتاحة: | https://publica.fraunhofer.de/handle/publica/218562 https://doi.org/10.1002/btpr.130 |
| رقم الانضمام: | edsbas.6D3FF461 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/btpr.130 |
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