Academic Journal
ASC modulates CTL cytotoxicity and transplant outcome independent of the inflammasome
| العنوان: | ASC modulates CTL cytotoxicity and transplant outcome independent of the inflammasome |
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| المؤلفون: | Cheong, Melody, Gartlan, Kate H., Lee, Jason S., Tey, Siok-Keen, Zhang, Ping, Kuns, Rachel D., Andoniou, Christopher E., Martins, Jose Paulo, Chang, Karshing, Sutton, Vivien R., Kelly, Greg, Varelias, Antiopi, Vuckovic, Slavica, Markey, Kate A., Boyle, Glen M., Smyth, Mark J., Engwerda, Christian R., MacDonald, Kelli P.A., Trapani, Joseph A., Degli-Esposti, Mariapia A., Koyama, Motoko, Hill, Geoffrey R. |
| بيانات النشر: | American Association for Cancer Research |
| سنة النشر: | 2020 |
| المجموعة: | The University of Queensland: UQ eSpace |
| مصطلحات موضوعية: | Immunology, Cancer Research, 1306 Cancer Research, 2403 Immunology |
| الوصف: | The adaptor protein ASC (apoptosis-associated speck-like protein containing a CARD) is known to facilitate caspase-1 activation, which is essential for innate host immunity via the formation of the inflammasome complex, a multiprotein structure responsible for processing IL1β and IL18 into their active moieties. Here, we demonstrated that ASC-deficient CD8+ T cells failed to induce severe graft-versus-host disease (GVHD) and had impaired capacity for graft rejection and graft-versus-leukemia (GVL) activity. These effects were inflammasome-independent because GVHD lethality was not altered in recipients of caspase-1/11-deficient T cells. We also demonstrated that ASC deficiency resulted in a decrease in cytolytic function, with a reduction in granzyme B secretion and CD107a expression by CD8+ T cells. Altogether, our findings highlight that ASC represents an attractive therapeutic target for improving outcomes of clinical transplantation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2326-6066 2326-6074 |
| Relation: | orcid:0000-0002-0343-1274; orcid:0000-0001-9567-382X; 1078671 %7C 1173958; Not set |
| الاتاحة: | https://espace.library.uq.edu.au/view/UQ:95b7dc9 |
| رقم الانضمام: | edsbas.6D3A7C23 |
| قاعدة البيانات: | BASE |
| تدمد: | 23266066 23266074 |
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