Academic Journal
Multidimensional Approach Assessing the Role of Interleukin 1 Beta in Mesial Temporal Lobe Epilepsy
| العنوان: | Multidimensional Approach Assessing the Role of Interleukin 1 Beta in Mesial Temporal Lobe Epilepsy |
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| المؤلفون: | Renato O. Santos, Rodrigo Secolin, Patrícia G. Barbalho, Mariana S. Silva-Alves, Marina K. M. Alvim, Clarissa L. Yasuda, Fábio Rogerio, Tonicarlo R. Velasco, Americo C. Sakamoto, Antonio L. Teixeira, Fernando Cendes, Claudia V. Maurer-Morelli, Iscia Lopes-Cendes |
| المصدر: | Frontiers in Neurology, Vol 12 (2021) |
| بيانات النشر: | Frontiers Media S.A. |
| سنة النشر: | 2021 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | mesial temporal sclerosis, hippocampal atrophy, association study, gene expression, neuroinflammation, Neurology. Diseases of the nervous system, RC346-429 |
| الوصف: | We aimed to investigate the role of interleukin-1 beta (IL-1β) in the mechanisms underlying mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE+HS). We assessed a cohort of 194 patients with MTLE+HS and 199 healthy controls. Patients were divided into those with positive and negative antecedent febrile seizures (FS). We used a multidimensional approach, including (i) genetic association with single nucleotide polymorphisms (SNPs) in the IL1B gene; (ii) quantification of the IL1B transcript in the hippocampal tissue of patients with refractory seizures; and (iii) quantification of the IL-1β protein in the plasma. We found a genetic association signal for two SNPs, rs2708928 and rs3730364*C in the IL1B gene, regardless of the presence of FS (adjusted p = 9.62e–11 and 5.14e–07, respectively). We found no difference between IL1B transcript levels when comparing sclerotic hippocampal tissue from patients with MTLE+HS, without FS, and hippocampi from autopsy controls (p > 0.05). Nevertheless, we found increased IL-1β in the plasma of patients with MTLE+HS with FS compared with controls (p = 0.0195). Our results support the hypothesis of a genetic association between MTLE+HS and the IL1B gene |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1664-2295 |
| Relation: | https://www.frontiersin.org/articles/10.3389/fneur.2021.690847/full; https://doaj.org/toc/1664-2295; https://doaj.org/article/b476dc37fe14460aacf656f18a4ab0c4 |
| DOI: | 10.3389/fneur.2021.690847 |
| الاتاحة: | https://doi.org/10.3389/fneur.2021.690847 https://doaj.org/article/b476dc37fe14460aacf656f18a4ab0c4 |
| رقم الانضمام: | edsbas.6D2FDDC7 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 16642295 |
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| DOI: | 10.3389/fneur.2021.690847 |