Academic Journal
No longer an untreatable disease: How targeted and immunotherapies have changed the management of melanoma patients
| العنوان: | No longer an untreatable disease: How targeted and immunotherapies have changed the management of melanoma patients |
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| المؤلفون: | Girotti, Maria Romina, Saturno, Grazia, Lorigan, Paul, Marais, Richard |
| المصدر: | Molecular Oncology ; volume 8, issue 6, page 1140-1158 ; ISSN 1574-7891 1878-0261 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2014 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | The discovery that BRAF is a driver oncogene in cancer, and complementary improvements in our understanding of the immune system have resulted in new targeted and immune‐therapies for metastatic melanoma. Targeted therapies achieve impressive clinical results in carefully selected patients but the development of resistance seems inevitable in most cases. Conversely, immune‐checkpoints inhibitors can achieve long‐term remission and cures, but in a smaller proportion of patients, and biomarkers to predict which patients will respond are not available. Nevertheless, melanoma has led the evolution of cancer treatment from relatively nonspecific cytotoxic agents to highly selective therapies and here we review the lessons from this paradigm shift in treatment and the opportunities for further improvements in outcomes for melanoma patients. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1016/j.molonc.2014.07.027 |
| الاتاحة: | http://dx.doi.org/10.1016/j.molonc.2014.07.027 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2Fj.molonc.2014.07.027 http://api.elsevier.com/content/article/PII:S1574789114001823?httpAccept=text/xml http://api.elsevier.com/content/article/PII:S1574789114001823?httpAccept=text/plain https://febs.onlinelibrary.wiley.com/doi/pdf/10.1016/j.molonc.2014.07.027 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.6D1DE2D7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.molonc.2014.07.027 |
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