Academic Journal
Reduced DNA Methylation of the Oxytocin Receptor Gene Is Associated With Anhedonia-Asociality in Women With Recent-Onset Schizophrenia and Ultra-high Risk for Psychosis
| العنوان: | Reduced DNA Methylation of the Oxytocin Receptor Gene Is Associated With Anhedonia-Asociality in Women With Recent-Onset Schizophrenia and Ultra-high Risk for Psychosis |
|---|---|
| المساهمون: | Minji Bang, Jee In Kang, Se Joo Kim, Jin Young Park, Kyung Ran Kim, Su Young Lee, Kyungmee Park, Eun Lee, Seung-Koo Lee, Suk Kyoon An, Kang, Jee In |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | anhedonia-asociality, epigenetics, schizophrenia, ultrahigh risk for psychosis, oxytocin receptor gene |
| الوصف: | Negative symptoms are recognized as a fundamental feature of schizophrenia throughout the disease course. Epigenetic alterations in the oxytocin receptor gene (OXTR) may be a key mechanism involved in social-emotional disturbances of schizophrenia. Here, we investigated OXTR methylation and its association with clinical and brain network connectivity phenotypes of negative symptoms, particularly anhedonia-asociality, in individuals with recent-onset schizophrenia (ROS) and at ultrahigh risk (UHR) for psychosis. Sixty-four ROS (39 women), 46 UHR (19 women), and 98 healthy individuals (52 women) participated in this study. OXTR methylation was quantified using the pyrosequencing method. A subset of participants (16 ROS, 23 UHR, and 33 healthy controls [HCs]) underwent a 5.5-minute resting-state functional magnetic resonance imaging to determine the relationship between OXTR methylation and the striatal-amygdala network functional connectivity (FC) underlying anhedonia-asociality. Both men and women with ROS and UHR showed significantly decreased OXTR methylation compared to HCs. In women with ROS and UHR, decreased OXTR methylation showed a significant correlation with increased anhedonia-asociality. FC of the striatal-amygdala network, positively associated with the severity of anhedonia-asociality, showed an inverse correlation with OXTR methylation. This study suggests that epigenetic alterations of OXTR, which can be detected before the development of full-blown psychosis, confer susceptibility to schizophrenia and play a crucial role in the manifestation of anhedonia-asociality, particularly in women. ; restriction |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0586-7614 1745-1701 |
| Relation: | SCHIZOPHRENIA BULLETIN; J02639; OAK-2019-05648; https://ir.ymlib.yonsei.ac.kr/handle/22282913/173279; https://academic.oup.com/schizophreniabulletin/article/45/6/1279/5434902; T201904428; SCHIZOPHRENIA BULLETIN, Vol.45(6) : 1279-1290, 2019; 63617 |
| DOI: | 10.1093/schbul/sbz016 |
| الاتاحة: | https://ir.ymlib.yonsei.ac.kr/handle/22282913/173279 https://doi.org/10.1093/schbul/sbz016 https://academic.oup.com/schizophreniabulletin/article/45/6/1279/5434902 |
| Rights: | CC BY-NC-ND 2.0 KR |
| رقم الانضمام: | edsbas.6D19A4DB |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 05867614 17451701 |
|---|---|
| DOI: | 10.1093/schbul/sbz016 |