Academic Journal
P0747 The real-world practice patterns and clinical outcomes of 5-aminosalicylic acid treatment in Korean patients with ulcerative colitis: a population-based retrospective study
العنوان: | P0747 The real-world practice patterns and clinical outcomes of 5-aminosalicylic acid treatment in Korean patients with ulcerative colitis: a population-based retrospective study |
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المؤلفون: | Park, S J, Park, S W, Kim, T I, Cheon, J H |
المصدر: | Journal of Crohn's and Colitis ; volume 19, issue Supplement_1, page i1446-i1446 ; ISSN 1873-9946 1876-4479 |
بيانات النشر: | Oxford University Press (OUP) |
سنة النشر: | 2025 |
الوصف: | Background This retrospective study analysed the real-world use patterns and clinical outcomes of 5-aminosalicylic acid (5-ASA) treatment in Korean patients with ulcerative colitis (UC) based on the records from national health insurance claims database (NHICD). Methods The records of individuals aged ≥15 years, first diagnosed as having UC between January 2009 and September 2018, were considered eligible for the study if 5-ASA was prescribed for ≥30 days within six months after the diagnosis. The data were extracted until the events of interest, patient’s death, or March 2019, whichever occurred earlier. The events of interest were defined as UC-related hospitalisation, UC-related surgery, and 5-ASA non-response, the latter corresponding to the prescription of steroids, immunosuppressants, and/or biological medications during the follow-up period. The yearly proportions of patients in each average daily dose (ADD) group, i.e., rectal monotherapy (RM), oral low dose (<2 g/day) monotherapy (OML), oral standard-to-high dose (2 g/day to ≥3 g/day) monotherapy, oral low dose combination therapy (OCL), and oral standard-to-high dose combination therapy (OCSH) group, were presented. Odds ratio for prescribing 5-ASA dose was calculated from a logistic regression model. The incidence of the events of interest was expressed per 1000 person-years (PY). Hazard ratios for 5-ASA non-response and UC-related hospitalisation in each ADD group were obtained from a Cox proportional hazard model, with OML as a reference group. Treatment adherence was expressed as a proportion of days covered (PDC) within the first 12 months from the prescription index date. Results The analysis included the data of 11,338 patients (mean age 42.15 years, 59.53% of males). During a median observation period of 1,720 days, a tendency to a decrease in RM proportion was observed, along with an increase in the proportions of oral + rectal combination therapies. The odds of prescribing high-dose 5-ASA increased significantly since 2013. ... |
نوع الوثيقة: | article in journal/newspaper |
اللغة: | English |
DOI: | 10.1093/ecco-jcc/jjae190.0921 |
الاتاحة: | https://doi.org/10.1093/ecco-jcc/jjae190.0921 https://academic.oup.com/ecco-jcc/article-pdf/19/Supplement_1/i1446/61545716/jjae190.0921.pdf |
Rights: | https://academic.oup.com/pages/standard-publication-reuse-rights |
رقم الانضمام: | edsbas.6D01D9F5 |
قاعدة البيانات: | BASE |
DOI: | 10.1093/ecco-jcc/jjae190.0921 |
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