Academic Journal
Correlation Between Detection Of Plasminogen Cross-Reactive Antibodies And Hemorrhage In Dengue Virus Infection
| العنوان: | Correlation Between Detection Of Plasminogen Cross-Reactive Antibodies And Hemorrhage In Dengue Virus Infection |
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| المؤلفون: | Chungue, Eliane, Poli, Lucien, Roche, Claudine, Gestas, Philippe, Glaziou, Philippe, Markoff, Lewis J. |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 1994 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | Concise Communications |
| الوصف: | Although dengue fever (DF) is usually self-limited, some patients experience severe and prolonged illness characterized by capillary leakage, which may progress to hypovolemic shock (dengue hemorrhagic fever/dengue shock syndrome; DHF/DSS) with hemorrhage of unknown etiology. Development of antibodies potentially cross-reactive to plasminogen has been reported in a high percentage of Thai patients with DF and DHF/DSS. Correlation between detection of plasminogen cross-reactive antibodies and hemorrhage was evaluated in 88 Tahitian children with dengue virus type 3 infection who presented with (n = 59) or without (n = 29) hemorrhage. Plasminogen cross-reactive antibodies were found in acute and convalescent sera of 33 and 11 children, respectively (56% vs. 31%, P < .05), and closely paralleled antibodies to the cross-reactive site in dengue virus E protein. Antibodies were more frequent in children with secondary than primary infections (60% vs. 32%, P < .05). Plasminogen cross-reactive antibodies did not correlate with occurrence of DHF/DSS or thrombocytopenia. These results are consistent with the possibility that plasminogen cross-reactive antibodies playa role in the etiology of hemorrhage in dengue virus infection. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| Relation: | http://jid.oxfordjournals.org/cgi/content/short/170/5/1304; http://dx.doi.org/10.1093/infdis/170.5.1304 |
| DOI: | 10.1093/infdis/170.5.1304 |
| الاتاحة: | http://jid.oxfordjournals.org/cgi/content/short/170/5/1304 https://doi.org/10.1093/infdis/170.5.1304 |
| Rights: | Copyright (C) 1994, Infectious Diseases Society of America |
| رقم الانضمام: | edsbas.6CC16BD8 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/infdis/170.5.1304 |
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