Academic Journal
Low thyroid function is not associated with an accelerated deterioration in renal function
| العنوان: | Low thyroid function is not associated with an accelerated deterioration in renal function |
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| المؤلفون: | Meuwese C. L., Van Diepen M., Cappola A. R., Sarnak M. J., Shlipak M. G., Bauer D. C., Fried L. P., Iacoviello M., Vaes B., Degryse J., Khaw K. -T., Luben R. N., Asvold B. O., Bjoro T., Vatten L. J., De Craen A. J. M., Trompet S., Iervasi G., Molinaro S., Ceresini G., Ferrucci L., Dullaart R. P. F., Bakker S. J. L., Jukema J. W., Kearney P. M., Stott D. J., Peeters R. P., Franco O. H., Volzke H., Walsh J. P., Bremner A., Sgarbi J. A., MacIel R. M. B., Imaizumi M., Ohishi W., Dekker F. W., Rodondi N., Gussekloo J., Den Elzen W. P. J. |
| المساهمون: | Meuwese, C. L., Van Diepen, M., Cappola, A. R., Sarnak, M. J., Shlipak, M. G., Bauer, D. C., Fried, L. P., Iacoviello, M., Vaes, B., Degryse, J., Khaw, K. -T., Luben, R. N., Asvold, B. O., Bjoro, T., Vatten, L. J., De Craen, A. J. M., Trompet, S., Iervasi, G., Molinaro, S., Ceresini, G., Ferrucci, L., Dullaart, R. P. F., Bakker, S. J. L., Jukema, J. W., Kearney, P. M., Stott, D. J., Peeters, R. P., Franco, O. H., Volzke, H., Walsh, J. P., Bremner, A., Sgarbi, J. A., Maciel, R. M. B., Imaizumi, M., Ohishi, W., Dekker, F. W., Rodondi, N., Gussekloo, J., Den Elzen, W. P. J. |
| سنة النشر: | 2019 |
| المجموعة: | Università degli Studi di Foggia: CINECA IRIS Institutional Research Information System |
| مصطلحات موضوعية: | chronic renal failure, CKD, creatinine clearance, epidemiology, thyroid function, Aged, 80 and over, Cross-Sectional Studie, Female, Glomerular Filtration Rate, Human, Incidence, Longitudinal Studie, Male, Meta-Analysis as Topic, Middle Aged, Netherland, Prognosi, Renal Insufficiency, Chronic, Thyroid Disease, Thyroid Function Test, Thyroid Hormones |
| الوصف: | Background: Chronic kidney disease (CKD) is frequently accompanied by thyroid hormone dysfunction. It is currently unclear whether these alterations are the cause or consequence of CKD. This study aimed at studying the effect of thyroid hormone alterations on renal function in cross-sectional and longitudinal analyses in individuals from all adult age groups. Methods: Individual participant data (IPD) from 16 independent cohorts having measured thyroid stimulating hormone, free thyroxine levels and creatinine levels were included. Thyroid hormone status was defined using clinical cut-off values. Estimated glomerular filtration rates (eGFR) were calculated by means of the four-variable Modification of Diet in Renal Disease (MDRD) formula. For this IPD meta-analysis, eGFR at baseline and eGFR change during follow-up were computed by fitting linear regression models and linear mixed models in each cohort separately. Effect estimates were pooled using random effects models. Results: A total of 72 856 individuals from 16 different cohorts were included. At baseline, individuals with overt hypothyroidism (n = 704) and subclinical hypothyroidism (n = 3356) had a average (95% confidence interval)-4.07 (-6.37 to-1.78) and-2.40 (-3.78 to-1.02) mL/min/1.73 m2 lower eGFR as compared with euthyroid subjects (n = 66 542). In (subclinical) hyperthyroid subjects (n = 2254), average eGFR was 3.01 (1.50-4.52) mL/min/1.73 m2 higher. During 329 713 patient years of follow-up, eGFR did not decline more rapidly in individuals with low thyroid function compared with individuals with normal thyroid function. Conclusions: Low thyroid function is not associated with a deterioration of renal function. The cross-sectional association may be explained by renal dysfunction causing thyroid hormone alterations. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/29684213; info:eu-repo/semantics/altIdentifier/wos/WOS:000466856500016; volume:34; issue:4; firstpage:650; lastpage:659; numberofpages:10; journal:NEPHROLOGY DIALYSIS TRANSPLANTATION; http://hdl.handle.net/11369/390251; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85064579058 |
| DOI: | 10.1093/ndt/gfy071 |
| الاتاحة: | http://hdl.handle.net/11369/390251 https://doi.org/10.1093/ndt/gfy071 |
| رقم الانضمام: | edsbas.6C995A33 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/ndt/gfy071 |
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