Academic Journal
Outcomes of Radioactive Iodine Versus Surgery for the Treatment of Graves’ Disease: a Systematic Review and Meta-analysis
| العنوان: | Outcomes of Radioactive Iodine Versus Surgery for the Treatment of Graves’ Disease: a Systematic Review and Meta-analysis |
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| المؤلفون: | Salman, Mohamed AbdAlla, Assal, Mohamed Moustafa, Salman, Ahmed, Elsherbiney, Mohammed |
| المساهمون: | Kasr El-Aini Hospital |
| المصدر: | Indian Journal of Surgery ; ISSN 0972-2068 0973-9793 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2023 |
| الوصف: | Graves’ disease (GD) is a systemic autoimmune disorder mainly affecting the thyroid gland. During GD management, the principal target is to control the hyperthyroid state. There have been three rather similarly effective modalities: medical therapy with antithyroid drugs (ATD), radioactive iodine (RAI), or surgical excision of the thyroid tissue (thyroidectomy). Defining the relative risks and benefits of each of the two potential definitive treatment options (RAI or thyroidectomy) is crucial for creating evidence-based therapy algorithms. This systematic review and meta-analysis aimed to compare the outcomes of these two treatment options. This is a systematic review and meta-analysis that analyzed the studies comparing RAI and thyroidectomy to treat GD. Studies were obtained by searching on Scopus, the Cochrane Central Register of Controlled Trials, and PubMed central database. The surgically treated group showed significantly lower failure rates, non-significantly lower cardiovascular morbidities, non-significantly higher complication rates, and significantly lower mortality rates. The RAI-related complications were mostly the development or worsening of Graves’ ophthalmopathy. This review and meta-analysis comparing surgery and radioactive iodine for the treatment of Grave’s disease from 16 well-conducted trials has shown that although surgery viz., total thyroidectomy was less frequently utilized for the treatment of Grave’s disease, it controlled the symptoms with greater success and without any worsening of Grave’s ophthalmopathy. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1007/s12262-023-03692-5 |
| DOI: | 10.1007/s12262-023-03692-5.pdf |
| DOI: | 10.1007/s12262-023-03692-5/fulltext.html |
| الاتاحة: | http://dx.doi.org/10.1007/s12262-023-03692-5 https://link.springer.com/content/pdf/10.1007/s12262-023-03692-5.pdf https://link.springer.com/article/10.1007/s12262-023-03692-5/fulltext.html |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.6C8C47E9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s12262-023-03692-5 |
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