Academic Journal
Effect of curcumin on bone healing: An experimental study in a rat model of femur fracture
| العنوان: | Effect of curcumin on bone healing: An experimental study in a rat model of femur fracture |
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| المؤلفون: | Safali, Selim., Aydin, Bahattin Kerem., Nayman, Alaaddin., Ugurluoglu, Ceyhan. |
| المساهمون: | Selçuk Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Safali, Selim., Aydin, Bahattin Kerem., Nayman, Alaaddin., Ugurluoglu, Ceyhan. |
| بيانات النشر: | ELSEVIER SCI LTD |
| سنة النشر: | 2019 |
| المجموعة: | Selçuk Üniversitesi: SÜ Sosyal Bilimler Enstitüsü - Dergisi Açık Arşivi |
| مصطلحات موضوعية: | Rat, Femur, Fracture healing, Curcumin |
| الوصف: | WOS: 000497290900017 ; PubMed: 31506168 ; Objective: To determine the radiologic, histologic and biomechanical effects of curcumin on bone healing using a total rat femur fracture injury model. Materials and methods: Sixty four male Wistar-Albino rats weighing 170-210 g were used in this study. The animals were randomly divided into eight groups and 5 or 6 animals were placed in each cage. A transverse femur shaft fracture model used. The animals in study groups received oral curcumin at a dose of 200 mg/kg for 14 days or 28 days. Remaining animals received only saline solution by oral gavage for a period of 14 days and 28 days as control groups. After sacrification the left femurs used for radiological, histological and biomechanical evaluation. Results: The groups treated with curcumin showed no significant difference in terms of radiological, histological and biomechanical evaluations in 14 days groups. Also there was no significant difference between curcumin and control groups for 28 days according to radiological, histological and biomechanical tests. Conclusions: According to our results, curcumin has no positive effect on fracture healing not only histologically but also radiologically and biomechanically. Curcumin's antioxidant effect may be more noticeable with long term follow up investigation as it may have a positive effect in remodelling phase. Long term follow up designed studies may be planned to investigate its effect on remodelling phase of fracture healing. (C) 2019 Elsevier Ltd. All rights reserved. ; Selcuk University Scientific Research OfficeSelcuk University ; This study was funded by Selcuk University Scientific Research Office. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0020-1383 1879-0267 |
| Relation: | INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; Safali, S., Aydin, B. K., Nayman, A., Ugurluoglu, C. (2019). Effect of Curcumin on Bone Healing: An Experimental Study in a Rat Model of Femur Fracture. Injury, 50(11), 1915-1920.; https://dx.doi.org/10.1016/j.injury.2019.09.002; https://hdl.handle.net/20.500.12395/37723; 50; 11; 1915; 1920 |
| DOI: | 10.1016/j.injury.2019.09.002 |
| الاتاحة: | https://hdl.handle.net/20.500.12395/37723 https://doi.org/10.1016/j.injury.2019.09.002 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.6C7D00C1 |
| قاعدة البيانات: | BASE |
| تدمد: | 00201383 18790267 |
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| DOI: | 10.1016/j.injury.2019.09.002 |