Academic Journal
Acute rejection in the absence of cognate recognition of allograft by T cells.
| العنوان: | Acute rejection in the absence of cognate recognition of allograft by T cells. |
|---|---|
| المؤلفون: | Braun, Michel Y, Grandjean, I, Feunou, Pascal, Duban, L, Kiss, Robert, Goldman, Michel, Lantz, O |
| المصدر: | The Journal of immunology, 166 (8 |
| سنة النشر: | 2001 |
| المجموعة: | DI-fusion : dépôt institutionnel de l'Université libre de Bruxelles (ULB) |
| مصطلحات موضوعية: | Sciences bio-médicales et agricoles, Acute Disease, Adoptive Transfer, Amino Acid Sequence, Animals, CD4-Positive T-Lymphocytes -- immunology, CD4-Positive T-Lymphocytes -- metabolism, CD4-Positive T-Lymphocytes -- transplantation, Epitopes, T-Lymphocyte -- immunology, Female, Graft Rejection -- genetics, Graft Rejection -- immunology, Graft Rejection -- pathology, H-2 Antigens -- immunology, Immunophenotyping, Interphase -- immunology, Lymphocyte Activation, Male, Mice, Inbred C3H, Inbred C57BL, Knockout, Transgenic, Molecular Sequence Data, Sex Factors, Skin Transplantation -- immunology, Skin Transplantation -- pathology, T-Lymphocyte Subsets -- immunology, T-Lymphocyte Subsets -- metabolism |
| الوصف: | We studied the effects of the indirect pathway of allograft recognition using T cells from TCR transgenic Marilyn mice, which recognize the male Ag H-Y in an I-A(b)-restricted fashion. The T cells are not alloreactive to the H-2(k) haplotype, because they are not activated when adoptively transferred into recombinase-activating gene-2(-/-) common gamma-chain(-/-) double-mutant H-2(k) male or female mice. However, skin from H-2(k) males, but not from H-2(k) females, is acutely rejected by recombinase-activating gene-2(-/-) transgenic female recipients. In vitro, Marylin spleen cells primed by H-2(k) skin grafting proliferated and secreted both IL-4 and IFN-gamma in response to H-2(k) male stimulators. However, the removal of H-2(b) APC from the responding population abolished the response. Taken together, these results show that the indirect recognition that triggers rejection in this model is due to the recognition of H-Y Ag shed from H-2(k) male allograft and presented by the recipient's own I-A(b) APC to transgenic T cells. This study demonstrates unequivocally the capacity of naive CD4(+) T cells to promote the rejection of allografts through mechanisms that involve indirect destruction of grafted tissues. ; Journal Article ; Research Support, Non-U.S. Gov't ; info:eu-repo/semantics/published |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 1 full-text file(s): application/pdf |
| اللغة: | English |
| Relation: | uri/info:pmid/11290764; uri/info:scp/0035871704; https://dipot.ulb.ac.be/dspace/bitstream/2013/50340/1/BraunetalJImm2001.pdf; http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/50340 |
| الاتاحة: | http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/50340 https://dipot.ulb.ac.be/dspace/bitstream/2013/50340/1/BraunetalJImm2001.pdf |
| رقم الانضمام: | edsbas.6C680EFB |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |