Academic Journal
Cytoplasmic P53 Immunostaining With N-Terminus P53 Antibody And Absence Of Staining With C-Terminus P53 Antibody: A Report Of Two Pediatric Sarcomas With Distal Truncating TP53 Mutations Affecting Nuclear Localization Domain
| العنوان: | Cytoplasmic P53 Immunostaining With N-Terminus P53 Antibody And Absence Of Staining With C-Terminus P53 Antibody: A Report Of Two Pediatric Sarcomas With Distal Truncating TP53 Mutations Affecting Nuclear Localization Domain |
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| المؤلفون: | Mirbaha, Hilda, Carrillo, Deyssy, Mitui, Midori, Hiemenz, Matthew C., Singh, Vivekanand, Rakheja, Dinesh |
| المصدر: | International Journal of Surgical Pathology ; volume 30, issue 4, page 457-461 ; ISSN 1066-8969 1940-2465 |
| بيانات النشر: | SAGE Publications |
| سنة النشر: | 2021 |
| الوصف: | P53 immunohistochemical staining with antibodies targeted to epitopes at or near the N-terminus are commonly used in diagnostic pathology practice as a surrogate for TP53 mutations. The abnormal staining patterns indicating TP53 mutations include nuclear overexpression, null, and the recently described cytoplasmic staining. The latter staining pattern occurs with the less common TP53 mutations affecting its nuclear localization and/or tetramerization domains that are located toward the C-terminus. Here we describe the first two cases of pediatric sarcomas with cytoplasmic staining with P53 antibody against N-terminus epitope and the absence of staining with P53 antibody against C-terminus epitope. We propose that a more precise description of P53 immunohistochemical staining patterns should include the nature of the antibody used. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1177/10668969211065115 |
| الاتاحة: | http://dx.doi.org/10.1177/10668969211065115 http://journals.sagepub.com/doi/pdf/10.1177/10668969211065115 http://journals.sagepub.com/doi/full-xml/10.1177/10668969211065115 |
| Rights: | http://journals.sagepub.com/page/policies/text-and-data-mining-license |
| رقم الانضمام: | edsbas.6BE0AACC |
| قاعدة البيانات: | BASE |
| DOI: | 10.1177/10668969211065115 |
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