Academic Journal
Transplacental transfer of cefuroxime in uncomplicated pregnancies and those complicated by hydrops or changes in amniotic fluid volume.
| العنوان: | Transplacental transfer of cefuroxime in uncomplicated pregnancies and those complicated by hydrops or changes in amniotic fluid volume. |
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| المؤلفون: | Holt, D E, Fisk, N M, Spencer, J A, de Louvois, J, Hurley, R, Harvey, D |
| بيانات النشر: | British Medical Journal Publishing Group |
| سنة النشر: | 1993 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | Research Article |
| الوصف: | The transplacental transfer of cefuroxime was determined at antenatal fetal blood sampling in a cross sectional study of 78 patients between 15-35 weeks' gestation, 8-138 minutes after a maternal intravenous dose of 750 mg. Mean serum cefuroxime concentration, measured by high performance liquid chromatography, was 7.4 (95% confidence interval (CI) 6.8 to 8.1) mg/l in control fetuses; concentrations in hydropic fetuses were similar (6.2 mg/l, CI 4.7 to 7.7) but in fetuses with oligohydramnios they were significantly lower, (4.9 mg/l, CI 3.6 to 6.2). Antibiotic concentration did not correlate with gestational age and remained unchanged by transfusion of packed red cells. We conclude that (i) fetal serum concentrations of cefuroxime obtained after a maternal dose of 750 mg are only adequate for prophylaxis against organisms with a minimum inhibitory concentration of < 4 mg/l and (ii) transplacental passage of cefuroxime is significantly reduced in the presence of oligohydramnios. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| Relation: | http://adc.bmj.com/cgi/content/short/68/1_Spec_No/54; http://dx.doi.org/10.1136/adc.68.1_Spec_No.54 |
| DOI: | 10.1136/adc.68.1_Spec_No.54 |
| الاتاحة: | http://adc.bmj.com/cgi/content/short/68/1_Spec_No/54 https://doi.org/10.1136/adc.68.1_Spec_No.54 |
| Rights: | Copyright (C) 1993, BMJ Publishing Group Ltd |
| رقم الانضمام: | edsbas.6BDE8A77 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1136/adc.68.1_Spec_No.54 |
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