Academic Journal
Population Pharmacokinetic–Pharmacodynamic Modeling of Granulocyte Colony‐Stimulating Factor to Optimize Dosing and Timing for CD34 + Cell Harvesting
| العنوان: | Population Pharmacokinetic–Pharmacodynamic Modeling of Granulocyte Colony‐Stimulating Factor to Optimize Dosing and Timing for CD34 + Cell Harvesting |
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| المؤلفون: | Jiang, Xu, Cha, Jun Seok, Jin, Byung Hak, Kim, Choon Ok, Chae, Dongwoo |
| المصدر: | Clinical and Translational Science ; volume 18, issue 1 ; ISSN 1752-8054 1752-8062 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2025 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Granulocyte colony‐stimulating factor (G‐CSF) mobilizes peripheral blood (PB) progenitor cells from bone marrow (BM) into circulation for PB stem cell transplantation (PBSCT). This study aimed to develop a population pharmacokinetic–pharmacodynamic (PK‐PD) model of filgrastim in healthy subjects to optimize PB CD34 + cell collection. Plasma filgrastim concentrations and CD34 + cell count data were obtained from a clinical study involving healthy Korean subjects. A total of 1378 plasma concentration measurements and 982 CD34 + cell count data collected from 53 subjects were used in the PK‐PD model. Filgrastim PKs were adequately described by a one‐compartment linear disposition model with an additional transit compartment for absorption. Log‐transformed body weight was the only significant covariate affecting the volume of distribution and clearance. CD34 + cell mobilization was best captured by a modified Friberg model, assuming continual entry of proliferating BM stem cells into PB via a single transit compartment. Simulation results suggested that the 5 μg/kg twice‐daily dosing regimen may yield higher CD34 + cell counts compared to the 10 μg/kg once‐daily regimen for achieving target CD34 + cell counts of 20/μL and 50/μL. We successfully developed a robust PK‐PD model of G‐CSF that optimizes the yield of CD34 + cells during allogeneic PBSCT. This model can guide the efficient determination of optimal G‐CSF dosing regimens and CD34 + cell harvesting strategies. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/cts.70121 |
| الاتاحة: | https://doi.org/10.1111/cts.70121 https://ascpt.onlinelibrary.wiley.com/doi/pdf/10.1111/cts.70121 |
| Rights: | http://creativecommons.org/licenses/by-nc/4.0/ |
| رقم الانضمام: | edsbas.6B69954E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/cts.70121 |
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