Academic Journal
Altered metabolic parameters in association with antipsychotic medication use in diabetes:A population based case-control study
| العنوان: | Altered metabolic parameters in association with antipsychotic medication use in diabetes:A population based case-control study |
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| المؤلفون: | Wake, D. J., Broughton, P., Perera, S. M., MacIntyre, D. J., Leese, G. P. |
| المصدر: | Wake , D J , Broughton , P , Perera , S M , MacIntyre , D J & Leese , G P 2016 , ' Altered metabolic parameters in association with antipsychotic medication use in diabetes : A population based case-control study ' , Psychoneuroendocrinology , vol. 66 , pp. 214-220 . https://doi.org/10.1016/j.psyneuen.2016.01.022 |
| سنة النشر: | 2016 |
| المجموعة: | Discovery - University of Dundee Online Publications |
| مصطلحات موضوعية: | Antipsychotics, Case-control, Diabetes, Mental health, Metabolic, Schizophrenia, /dk/atira/pure/subjectarea/asjc/1300/1310, name=Endocrinology, /dk/atira/pure/subjectarea/asjc/2700/2712, Diabetes and Metabolism, /dk/atira/pure/subjectarea/asjc/2700/2738, name=Psychiatry and Mental health, /dk/atira/pure/subjectarea/asjc/2800/2803, name=Biological Psychiatry, /dk/atira/pure/subjectarea/asjc/2800/2807, name=Endocrine and Autonomic Systems |
| الوصف: | Aims: This study assess differences in clinical variables in diabetes patients prescribed antipsychotic medication and determines relative schizophrenia prevalence in the diabetes population. Methods: This population-based case-control study utilizing Scotland's national diabetes registry (SCI-diabetes) and linked psychiatric hospital discharge data (SMR04) established diabetes phenotypes in a patient cohort prescribed long term antipsychotic medication (n = 2362) (cases). Cases were matched 1:10 to diabetes patients not prescribed antipsychotic medication (controls) for BMI, gender; diabetes type; birth year; diagnosis date; smoking status. Sub-groups with defined schizophrenia (n = 196) or bipolar disorder (n = 190) were further examined. Schizophrenia prevalence in the diabetes versus general population was compared. Results: During follow up, antipsychotic prescription was associated with lower HbA1c (55.1 (95% CI 54.5-55.8) or 7.2 (95% CI 7.1-7.3)% vs 58.2 (58.0-58.4) mmol or 7.5 (95% CI 7.5-7.5)% p <0.001) lower serum total cholesterol, 4.2 (4.1-4.2) vs 4.3 (4.2-4.3) mmol/l, p <0.001, lower blood pressure (systolic 130 (130.17-131.29) vs 134 (134.3-134.7) mmHg, p <0.001), higher prescription of oral hypoglycaemic medication (42% (40-45) vs 38% (37-39) p <0.001), similar statin prescriptions (85% (81-89) vs 85% (84-86), p = 0.55), and lower retinopathy rates (28% (25.6-30.5) vs 32% (31.5-33.1), p <0.001). HbA1c at diagnosis was similar (p = 0.27). Schizophrenia prevalence was higher in the diabetes versus general population with differences across age groups (Scottish population versus diabetic population rate of 522.2 (522.1-522.3) versus 717.4 (703.4-731.9) per 100,000). Conclusions: We confirm higher diabetes rates in schizophrenia up to age 70, similar attendance rates and clinical measurements that are not worse in a large well-matched population-based Scottish sample prescribed antipsychotic medication versus matched general diabetes patients. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | https://discovery.dundee.ac.uk/en/publications/03d2e273-de2a-46ab-b0b1-bc966888fd59 |
| DOI: | 10.1016/j.psyneuen.2016.01.022 |
| الاتاحة: | https://discovery.dundee.ac.uk/en/publications/03d2e273-de2a-46ab-b0b1-bc966888fd59 https://doi.org/10.1016/j.psyneuen.2016.01.022 https://discovery.dundee.ac.uk/ws/files/11914396/Diabetes_Antipsychotic_PNEC_revised.pdf http://www.scopus.com/inward/record.url?scp=84960873333&partnerID=8YFLogxK |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.6B5788FC |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.psyneuen.2016.01.022 |
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