Academic Journal
Negligible risk of prenatal ductus arteriosus closure or fetal renal impairment after third‐trimester paracetamol use: evaluation of the German Embryotox cohort
| العنوان: | Negligible risk of prenatal ductus arteriosus closure or fetal renal impairment after third‐trimester paracetamol use: evaluation of the German Embryotox cohort |
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| المؤلفون: | Dathe, K, Frank, J, Padberg, S, Hultzsch, S, Meixner, K, Beck, E, Meister, R, Schaefer, C |
| المصدر: | BJOG: An International Journal of Obstetrics & Gynaecology ; volume 126, issue 13, page 1560-1567 ; ISSN 1470-0328 1471-0528 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2019 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Objective Risk of fetotoxicity after paracetamol exposure in the third trimester. Design Observational cohort study and retrospective case assessment. Setting Germany, 2008–2017. Population Pregnant women exposed to paracetamol. Methods Prospectively enrolled third‐trimester pregnancies that had been exposed to paracetamol (604) were compared with pregnancies exposed to paracetamol in the first and/or second trimester only (1192). Exclusion criteria were exposure to nonsteroidal anti‐inflammatory drugs ( NSAID s) in the second or third trimester. Additionally, the Embryotox ‘adverse drug reaction in pregnancy’ database was screened for cases of fetotoxicity. Main outcome measures The prenatal study end points focused on narrowing or closure of ductus arteriosus Botalli, late fetal death, and oligohydramnios. The postnatal end points included patent ductus arteriosus (PDA), primary pulmonary hypertension (PPHT), and impaired renal function. Results In both cohorts, no fetus with intrauterine narrowing or closure of the ductus arteriosus Botalli was reported (0/604 versus 0/1192). Oligohydramnios was diagnosed at a similar frequency in both cohorts: 1.3% (8/604) versus 1.6% (19/1192). There was one stillbirth in the study cohort (1/604, 0.2%) and four stillbirths in the comparison cohort (4/1192, 0.3%). The rates of PDA in neonates were similar: 0.7% (4/615) versus 0.7% (9/1212). PPHT as well as serious postnatal renal disorders were reported once in each cohort. In 12 out of 96 retrospective cases, there were indicators for study end points; however, co‐exposure to NSAID s or complex situations weaken the assumption of paracetamol toxicity. Conclusions Fetal cardiovascular or renal toxicity of maternal third‐trimester paracetamol use appears to be negligible. Tweetable abstract Paracetamol use in the third trimester does not seem to be associated with a relevant risk of fetotoxicity. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/1471-0528.15872 |
| الاتاحة: | http://dx.doi.org/10.1111/1471-0528.15872 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2F1471-0528.15872 https://onlinelibrary.wiley.com/doi/pdf/10.1111/1471-0528.15872 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/1471-0528.15872 https://obgyn.onlinelibrary.wiley.com/doi/pdf/10.1111/1471-0528.15872 |
| Rights: | http://creativecommons.org/licenses/by-nc/4.0/ |
| رقم الانضمام: | edsbas.6B53E59A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/1471-0528.15872 |
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