Academic Journal
Early-pregnancy transcriptome signatures of preeclampsia: from peripheral blood to placenta
| العنوان: | Early-pregnancy transcriptome signatures of preeclampsia: from peripheral blood to placenta |
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| المؤلفون: | Yadama, Aishwarya P., Maiorino, Enrico, Carey, Vincent J., McElrath, Thomas F., Litonjua, Augusto A., Loscalzo, Joseph, Weiss, Scott T., Mirzakhani, Hooman |
| المساهمون: | National Heart, Lung, and Blood Institute, National Institutes of Health, American Heart Association |
| المصدر: | Scientific Reports ; volume 10, issue 1 ; ISSN 2045-2322 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2020 |
| الوصف: | Several studies have linked maternal asthma, excess BMI, and low vitamin D status with increased risk of Preeclampsia (PE) development. Given prior evidence in the literature and our observations from the subjects in the Vitamin D Antenatal Asthma Reduction Trial (VDAART), we hypothesized that PE, maternal asthma, vitamin D insufficiency, and excess body mass index (BMI) might share both peripheral blood and placental gene signatures that link these conditions together. We used samples collected in the VDAART to investigate relationships between these four conditions and gene expression patterns in peripheral blood obtained at early pregnancy. We identified a core set of differentially expressed genes in all comparisons between women with and without these four conditions and confirmed them in two separate sets of samples. We confirmed the differential expression of the shared gene signatures in the placenta from an independent study of preeclampsia cases and controls and constructed the preeclampsia module using protein–protein interaction networks. CXC chemokine genes showed the highest degrees of connectivity and betweenness centrality in the peripheral blood and placental modules. The shared gene signatures demonstrate the biological pathways involved in preeclampsia at the pre-clinical stage and may be used for the prediction of preeclampsia. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s41598-020-74100-1 |
| الاتاحة: | http://dx.doi.org/10.1038/s41598-020-74100-1 https://www.nature.com/articles/s41598-020-74100-1.pdf https://www.nature.com/articles/s41598-020-74100-1 |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.6B4F8181 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41598-020-74100-1 |
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