Academic Journal
Thermoresponsive Injectable Hydrogel To Mimic the Heat- and Strain-Stiffening Behavior of Biopolymers toward Muscle Cell Proliferation
| العنوان: | Thermoresponsive Injectable Hydrogel To Mimic the Heat- and Strain-Stiffening Behavior of Biopolymers toward Muscle Cell Proliferation |
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| المؤلفون: | Debasish Nath, Jahanvi Ralhan, Jojo P. Joseph, Chirag Miglani, Asish Pal |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | Biophysics, Biochemistry, Genetics, Biotechnology, Ecology, Space Science, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, thermoresponsive injectable hydrogel, supramolecular peptide nanostructures, nonlinear mechanical attributes, demonstrate compression load, exhibit injectable behavior, stiffening behavior, twisted bundles, tissue engineering, thermosensitive aldehyde, living tissues, hydrogels transform, gel state, functionalized polymer, external stress, create scaffolds, biomechanical intricacies, bearing capabilities |
| الوصف: | Injectable hydrogels with nonlinear mechanical attributes to emulate natural biopolymers hold paramount significance in tissue engineering, offering the potential to create scaffolds that seamlessly mimic the biomechanical intricacies of living tissues. Herein, we unveil a synthetic design strategy employing Schiff base chemistry to furnish a peptide–polymer hierarchical contractile injectable hydrogel network. This innovative design demonstrates cross-linking of supramolecular peptide nanostructures such as nanofibers, 1 NF , and twisted bundles, 1 TB , with a thermosensitive aldehyde-functionalized polymer, P CHO . These networks exhibit interesting nonlinear mechanical stiffening responses to temperature and external stress. Furthermore, the hydrogels transform into a gel state at physiological temperature to exhibit injectable behavior and demonstrate compression load-bearing capabilities. Finally, the hydrogel network exhibits excellent biocompatibility and cell proliferation toward fibroblast, L929, and myoblast, C2C12, to validate their use as potential extracellular matrix mimetic injectable scaffolds. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | https://figshare.com/articles/journal_contribution/Thermoresponsive_Injectable_Hydrogel_To_Mimic_the_Heat-_and_Strain-Stiffening_Behavior_of_Biopolymers_toward_Muscle_Cell_Proliferation/24989858 |
| DOI: | 10.1021/acs.biomac.3c01018.s001 |
| الاتاحة: | https://doi.org/10.1021/acs.biomac.3c01018.s001 https://figshare.com/articles/journal_contribution/Thermoresponsive_Injectable_Hydrogel_To_Mimic_the_Heat-_and_Strain-Stiffening_Behavior_of_Biopolymers_toward_Muscle_Cell_Proliferation/24989858 |
| Rights: | CC BY-NC 4.0 |
| رقم الانضمام: | edsbas.6B42FDB8 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1021/acs.biomac.3c01018.s001 |
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