Academic Journal
Cellular and Molecular Mechanisms Underlying Non-Pharmaceutical Ischemic Stroke Therapy in Aged Subjects
| العنوان: | Cellular and Molecular Mechanisms Underlying Non-Pharmaceutical Ischemic Stroke Therapy in Aged Subjects |
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| المؤلفون: | Sandu, Raluca Elena, Dumbrava, Danut, Surugiu, Roxana, Glavan, Daniela-Gabriela, Gresita, Andrei, Petcu, Eugen Bogdan |
| بيانات النشر: | MDPI |
| سنة النشر: | 2018 |
| المجموعة: | Griffith University: Griffith Research Online |
| مصطلحات موضوعية: | Other chemical sciences, Other chemical sciences not elsewhere classified, Genetics, Other biological sciences |
| الوصف: | The incidence of ischemic stroke in humans increases exponentially above 70 years both in men and women. Comorbidities like diabetes, arterial hypertension or co-morbidity factors such as hypercholesterolemia, obesity and body fat distribution as well as fat-rich diet and physical inactivity are common in elderly persons and are associated with higher risk of stroke, increased mortality and disability. Obesity could represent a state of chronic inflammation that can be prevented to some extent by non-pharmaceutical interventions such as calorie restriction and hypothermia. Indeed, recent results suggest that H2S-induced hypothermia in aged, overweight rats could have a higher probability of success in treating stroke as compared to other monotherapies, by reducing post-stroke brain inflammation. Likewise, it was recently reported that weight reduction prior to stroke, in aged, overweight rats induced by caloric restriction, led to an early re-gain of weight and a significant improvement in recovery of complex sensorimotor skills, cutaneous sensitivity, or spatial memory. Conclusion: animal models of stroke done in young animals ignore age-associated comorbidities and may explain, at least in part, the unsuccessful bench-to-bedside translation of neuroprotective strategies for ischemic stroke in aged subjects. ; Full Text |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1661-6596 |
| Relation: | International Journal of Molecular Sciences; http://hdl.handle.net/10072/376008 |
| DOI: | 10.3390/ijms19010099 |
| الاتاحة: | http://hdl.handle.net/10072/376008 https://doi.org/10.3390/ijms19010099 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ ; © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). ; open access |
| رقم الانضمام: | edsbas.6B22927C |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 16616596 |
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| DOI: | 10.3390/ijms19010099 |