Academic Journal
Magnesium levels and outcome after allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia
| العنوان: | Magnesium levels and outcome after allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia |
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| المؤلفون: | Angenendt, Linus, Hilgefort, Isabel, Mikesch, Jan-Henrik, Schlüter, Bernhard, Berdel, Wolfgang E., Lenz, Georg, Stelljes, Matthias, Schliemann, Christoph |
| المصدر: | http://lobid.org/resources/99370678538206441#!, 100(7):1871-1878. |
| سنة النشر: | 2020 |
| المجموعة: | Publisso (ZB MED-Publikationsportal Lebenswissenschaften) |
| مصطلحات موضوعية: | Magnesium/blood [MeSH], Aged [MeSH], Leukemia, Myeloid, Acute/blood [MeSH], Original Article, Acute myeloid leukemia, Male [MeSH], Acute/therapy [MeSH], Graft vs Host Disease/blood [MeSH], Transplantation, Homologous [MeSH], Adolescent [MeSH], Female [MeSH], Follow-Up Studies [MeSH], Magnesium, Adult [MeSH], Humans [MeSH], Graft vs Leukemia Effect [MeSH], Treatment Outcome [MeSH], Acute/diagnosis [MeSH], Retrospective Studies [MeSH], Middle Aged [MeSH], Allogeneic hematopoietic stem cell transplantation, Hematopoietic Stem Cell Transplantation/adverse effects [MeSH], GVL, Graft vs Host Disease/diagnosis [MeSH], Prognosis [MeSH], Young Adult [MeSH], GVHD |
| الوصف: | Low intake of magnesium has been associated with the occurrence of lymphomas and decreased magnesium levels suppress the cytotoxic function of T cells and natural killer cells in patients with 'X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection, and neoplasia' (XMEN) syndrome. These cell types are also important mediators of immune-mediated effects after allogeneic hematopoietic stem cell transplantation. Here, we show that high posttransplant magnesium levels independently associate with a lower incidence of relapse, a higher risk of acute graft-versus-host disease, and a higher non-relapse mortality in 368 patients with acute myeloid leukemia from our center. Magnesium serum levels might impact on donor-cell-mediated immune responses in acute myeloid leukemia. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://repository.publisso.de/resource/frl:6467036; https://doi.org/10.1007/s00277-020-04382-y; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8195955/ |
| DOI: | 10.1007/s00277-020-04382-y |
| الاتاحة: | https://repository.publisso.de/resource/frl:6467036 https://doi.org/10.1007/s00277-020-04382-y https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8195955/ |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.6B18DE0E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00277-020-04382-y |
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