Academic Journal
Small zinc doped iron oxide tracers for magnetic particle imaging
| العنوان: | Small zinc doped iron oxide tracers for magnetic particle imaging |
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| المؤلفون: | Kim Duong, HT, Abdibastami, A, Gloag, L, Bongers, A, Shanehsazzadeh, S, Nelson, M, Cousins, A, Bayat, N, McCalmont, H, Lock, RB, Sulway, S, Biazick, J, Justin Gooding, J, Tilley, RD, Gooding, Justin, Duong, Hong Thien Kim |
| المصدر: | urn:ISSN:0304-8853 ; urn:ISSN:1873-4766 ; Journal of Magnetism and Magnetic Materials, 587 |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2023 |
| المجموعة: | UNSW Sydney (The University of New South Wales): UNSWorks |
| مصطلحات موضوعية: | 40 Engineering, 4018 Nanotechnology, 4003 Biomedical Engineering, Nanotechnology, Bioengineering, anzsrc-for: 40 Engineering, anzsrc-for: 4018 Nanotechnology, anzsrc-for: 4003 Biomedical Engineering, anzsrc-for: 0204 Condensed Matter Physics, anzsrc-for: 0912 Materials Engineering, anzsrc-for: 0913 Mechanical Engineering, anzsrc-for: 4016 Materials engineering, anzsrc-for: 5104 Condensed matter physics |
| الوصف: | Magnetic particle imaging (MPI) has garnered significant attention in biomedical imaging research due to its excellent signal intensity that is generated directly from superparamagnetic iron oxide nanoparticles (SPIONs). Small nanoparticle tracers with high saturation magnetisation are crucial for MPI as they can prolong circulation, crossing the blood brain barrier and enhance cellular uptake. In this work, we demonstrate small zinc doped iron oxide nanoparticles (Zn-IONPs) are excellent MPI tracers. Our Zn-IONPs exhibited up to 37 % and 64% enhancement in saturation magnetisation (Msat) value and MPI signal intensity respectively compared to Fe3O4 of the same size. As a result, the polymer encapsulated Zn-IONPs achieved up to 2.7-fold enhancement in MPI signal intensity compared to VivoTrax. Furthermore, these polymer encapsulated NPs were also determined to be non-toxic hence making these Zn-IONPs ideal for many biomedical applications in MPI where small size is critical to prolong circulation time and crossing the blood brain barrier. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| Relation: | http://purl.org/au-research/grants/nhmrc/APP1091261; http://purl.org/au-research/grants/nhmrc/APP1157871; http://hdl.handle.net/1959.4/unsworks_84718; https://doi.org/10.1016/j.jmmm.2023.171304 |
| DOI: | 10.1016/j.jmmm.2023.171304 |
| الاتاحة: | http://hdl.handle.net/1959.4/unsworks_84718 https://unsworks.unsw.edu.au/bitstreams/e80b514e-5711-4537-805a-08bff3e9b32d/download https://doi.org/10.1016/j.jmmm.2023.171304 |
| Rights: | open access ; https://purl.org/coar/access_right/c_abf2 ; CC-BY ; https://creativecommons.org/licenses/by/4.0/ ; free_to_read ; This is an open access article is published by Elsevier under the terms of the Creative Commons CC-BY license (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| رقم الانضمام: | edsbas.6B151C7C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.jmmm.2023.171304 |
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