Academic Journal
Therapeutic Opportunities and Delivery Strategies for Brain Revascularization in Stroke, Neurodegeneration, and Aging
| العنوان: | Therapeutic Opportunities and Delivery Strategies for Brain Revascularization in Stroke, Neurodegeneration, and Aging |
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| المؤلفون: | Gallego Garrido, Idoia, Villate Beitia, Ane Ilia, Sáenz del Burgo Martínez, Laura, Puras Ochoa, Gustavo, Pedraz Muñoz, José Luis, Barker, Eric |
| بيانات النشر: | American Society of Pharmacology Experimental Therapeutics |
| سنة النشر: | 2022 |
| المجموعة: | ADDI: Repositorio Institucional de la Universidad del País Vasco / Euskal Herriko Unibertsitatea (UPV/EHU - Basque Country University) |
| الوصف: | [EN] Central nervous system (CNS) diseases, especially acute ischemic events and neurodegenerative disorders, constitute a public health problem with no effective treatments to allow a persistent solution. Failed therapies targeting neuronal recovery have revealed the multifactorial and intricate pathophysiology underlying such CNS disorders as ischemic stroke, Alzheimers disease, amyotrophic lateral sclerosis, vascular Parkisonism, vascular dementia, and aging, in which cerebral microvasculature impairment seems to play a key role. In fact, a reduction in vessel density and cerebral blood flow occurs in these scenarios, contributing to neuronal dysfunction and leading to loss of cognitive function. In this review, we provide an overview of healthy brain microvasculature structure and function in health and the effect of the aforementioned cerebral CNS diseases. We discuss the emerging new therapeutic opportunities, and their delivery approaches, aimed at recovering brain vascularization in this context. SIGNIFICANCE STATEMENT: The lack of effective treatments, mainly focused on neuron recovery, has prompted the search of other therapies to treat cerebral central nervous system diseases. The disruption and degeneration of cerebral microvasculature has been evidenced in neurodegenerative diseases, stroke, and aging, constituting a potential target for restoring vascularization, neuronal functioning, and cognitive capacities by the development of therapeutic pro-angiogenic strategies. ; This work was supported by the University of the Basque Country (UPV/EHU) [Grant ESPDOC19/47] (postdoctoral fellowship to I.V.B.); and the Basque Country Government (Consolidated Groups) [Grant IT907-16]. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1521-0081 |
| Relation: | https://pharmrev.aspetjournals.org/content/74/2/439; Pharmacological Reviews 74 : 439-461 (2022); http://hdl.handle.net/10810/56237 |
| DOI: | 10.1124/pharmrev.121.000418 |
| الاتاحة: | http://hdl.handle.net/10810/56237 https://doi.org/10.1124/pharmrev.121.000418 |
| Rights: | info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by-nc/3.0/es/ ; Copyright © 2022 by The Author(s). This is an open access article distributed under the CC BY-NC Attribution 4.0 International license ; Atribución-NoComercial 3.0 España |
| رقم الانضمام: | edsbas.6B0C24E4 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 15210081 |
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| DOI: | 10.1124/pharmrev.121.000418 |