Academic Journal
The rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under flow conditions.
| العنوان: | The rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under flow conditions. |
|---|---|
| المؤلفون: | Glöckner, Steffen, Tran, Duc N, Ingham, Richard J, Fenner, Sabine, Wilson, Zoe E, Battilocchio, Claudio, Ley, Steven V |
| بيانات النشر: | Royal Society of Chemistry (RSC) //doi.org/10.1039/c4ob02105c Org Biomol Chem |
| سنة النشر: | 2015 |
| المجموعة: | Apollo - University of Cambridge Repository |
| مصطلحات موضوعية: | Amides, Chemistry Techniques, Synthetic, Kinetics, Manganese Compounds, Oxazoles, Oxidation-Reduction, Oxides |
| الوصف: | A rapid flow synthesis of oxazolines and their oxidation to the corresponding oxazoles is reported. The oxazolines are prepared at room temperature in a stereospecific manner, with inversion of stereochemistry, from β-hydroxy amides using Deoxo-Fluor®. The corresponding oxazoles can then be obtained via a packed reactor containing commercial manganese dioxide. ; We are grateful to the Swiss National Science Foundation (DNT), the Ralph Raphael fellowship (RJI), the German Academic Exchange Service DAAD (SF), the Royal Society Newton International Fellowship (ZEW), Pfizer Worldwide Research and Development (CB) and the EPSRC (SVL, SF and ZEW, grant nº EP/K0099494/1) for financial support. The Labtrix Start was kindly loaned by Chemtrix BV and the liquid-liquid phase separator by Zaiput Flow Technologies (we are grateful to Dr Andrea Adamo for technical support with this device). ; This is the final version. It was first published by the Royal Society of Chemistry at http://dx.doi.org/10.1039/C4OB02105C |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | https://www.repository.cam.ac.uk/handle/1810/246399 |
| الاتاحة: | https://www.repository.cam.ac.uk/handle/1810/246399 |
| Rights: | Attribution-NonCommercial 2.0 UK: England & Wales ; http://creativecommons.org/licenses/by-nc/2.0/uk/ |
| رقم الانضمام: | edsbas.6AD62E64 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |