التفاصيل البيبلوغرافية
| العنوان: |
Sacubitril/Valsartan Improves Diastolic Function But Not Skeletal Muscle Function in a Rat Model of HFpEF |
| المؤلفون: |
Antje Schauer, Volker Adams, Antje Augstein, Anett Jannasch, Runa Draskowski, Virginia Kirchhoff, Keita Goto, Jeniffer Mittag, Roberta Galli, Anita Männel, Peggy Barthel, Axel Linke, Ephraim B. Winzer |
| المصدر: |
International Journal of Molecular Sciences; Volume 22; Issue 7; Pages: 3570 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2021 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
HFpEF, ZSF-1, Sacubitril/Valsartan, diastolic dysfunction, skeletal muscle dysfunction |
| جغرافية الموضوع: |
agris |
| الوصف: |
The angiotensin receptor/neprilysin inhibitor Sacubitril/Valsartan (Sac/Val) has been shown to be beneficial in patients suffering from heart failure with reduced ejection fraction (HFrEF). However, the impact of Sac/Val in patients presenting with heart failure with preserved ejection fraction (HFpEF) is not yet clearly resolved. The present study aimed to reveal the influence of the drug on the functionality of the myocardium, the skeletal muscle, and the vasculature in a rat model of HFpEF. Female obese ZSF-1 rats received Sac/Val as a daily oral gavage for 12 weeks. Left ventricle (LV) function was assessed every four weeks using echocardiography. Prior to organ removal, invasive hemodynamic measurements were performed in both ventricles. Vascular function of the carotid artery and skeletal muscle function were monitored. Sac/Val treatment reduced E/é ratios, left ventricular end diastolic pressure (LVEDP) and myocardial stiffness as well as myocardial fibrosis and heart weight compared to the obese control group. Sac/Val slightly improved endothelial function in the carotid artery but had no impact on skeletal muscle function. Our results demonstrate striking effects of Sac/Val on the myocardial structure and function in a rat model of HFpEF. While vasodilation was slightly improved, functionality of the skeletal muscle remained unaffected. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Biochemistry; https://dx.doi.org/10.3390/ijms22073570 |
| DOI: |
10.3390/ijms22073570 |
| الاتاحة: |
https://doi.org/10.3390/ijms22073570 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.6AC69555 |
| قاعدة البيانات: |
BASE |