Academic Journal
Inhibitory Effects of HangAmDan-B1 (HAD-B1) Combined With Afatinib on H1975 Lung Cancer Cell–Bearing Mice
| العنوان: | Inhibitory Effects of HangAmDan-B1 (HAD-B1) Combined With Afatinib on H1975 Lung Cancer Cell–Bearing Mice |
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| المؤلفون: | Kang, Hwa Jeong, Kim, Jeehye, Cho, Seong Hyeok, Park, So-Jung, Yoo, Hwa-Seung, Kang, In-Cheol |
| المساهمون: | Ministry of Education, Korea Health Industry Development Institute |
| المصدر: | Integrative Cancer Therapies ; volume 18 ; ISSN 1534-7354 1552-695X |
| بيانات النشر: | SAGE Publications |
| سنة النشر: | 2019 |
| الوصف: | Epidermal growth factor receptor mutation-positive non–small cell lung cancer is cared for mainly by target therapeutics in the clinical treatment at present. We investigated the antitumor effect of HangAmDan-B1 (HAD-B1) combined with afatinib on H1975 (L858R/T790M double mutation) lung cancer cells. The combined treatment of HAD-B1 with afatinib inhibited the proliferation of H1975 cells in a dose-dependent manner compared with the treatment of afatinib or HAD-B1 alone. The combined treatment group significantly induced early apoptosis and cell cycle arrest of the cells compared with afatinib- or HAD-B1-treated control group. Profile analysis of cell cycle proteins in H1975 cells treated with the combination of HAD-B1 and afatinib using InnoPharmaScreen antibody microarray showed downregulation of pERK1/2 and upregulation of p16 in the cells. In vivo tumor growth assay in xenograft animal model of human H1975 lung cancer cells revealed that the mean tumor volume in the group treated with the combination of HAD-B1 and afatinib showed a significant reduction compared with the control groups. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1177/1534735419830765 |
| الاتاحة: | https://doi.org/10.1177/1534735419830765 https://journals.sagepub.com/doi/pdf/10.1177/1534735419830765 https://journals.sagepub.com/doi/full-xml/10.1177/1534735419830765 |
| Rights: | https://journals.sagepub.com/page/policies/text-and-data-mining-license |
| رقم الانضمام: | edsbas.6AA60DBF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1177/1534735419830765 |
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