Academic Journal
Penetration of cefpodoxime proxetil in lung parenchyma and epithelial lining fluid of noninfected patients
| العنوان: | Penetration of cefpodoxime proxetil in lung parenchyma and epithelial lining fluid of noninfected patients |
|---|---|
| المؤلفون: | Muller-Serieys, C, Bancal, C, Dombret, M C, Soler, P, Murciano, G, Aubier, M, Bergogne-Berezin, E |
| المصدر: | Antimicrobial Agents and Chemotherapy ; volume 36, issue 10, page 2099-2103 ; ISSN 0066-4804 1098-6596 |
| بيانات النشر: | American Society for Microbiology |
| سنة النشر: | 1992 |
| الوصف: | The pulmonary disposition of cefpodoxime was studied in 12 patients with pulmonary opacities after a single oral dose of 260 mg of cefpodoxime-proxetil, which is equivalent to 200 mg of cefpodoxime. Blood and lung tissue samples were collected during surgery, and bronchoalveolar lavage was carried out 3 h (group A) or 6 h (group B) after drug administration. Urea was used as an endogenous marker for measurement of the volume of epithelial lining fluid (ELF). Concentrations were measured by using a microbiological assay. The mean concentrations of cefpodoxime in plasma, ELF, and lung tissue were, respectively, 1.85 +/- 0.82 mg/liter, 0.22 +/- 0.13 mg/liter, and 0.89 +/- 0.80 mg/kg of body weight in group A and 1.40 +/- 1.25 mg/liter, 0.12 +/- 0.14 mg/liter, and 0.84 +/- 0.61 mg/kg in group B. Concentrations in lung parenchyma 6 h after dosing were at least equal to or above the MICs for 90% of the strains of most organisms commonly found in respiratory tract infections, whereas data for ELF suggest levels of drug insufficient to inhibit bacteria. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1128/aac.36.10.2099 |
| DOI: | 10.1128/AAC.36.10.2099 |
| الاتاحة: | http://dx.doi.org/10.1128/aac.36.10.2099 https://journals.asm.org/doi/pdf/10.1128/AAC.36.10.2099 |
| Rights: | https://journals.asm.org/non-commercial-tdm-license |
| رقم الانضمام: | edsbas.6A6D5847 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1128/aac.36.10.2099 |
|---|