التفاصيل البيبلوغرافية
| العنوان: |
Depletion of CCN1/CYR61 reduces triple-negative/basal-like breast cancer aggressiveness |
| المؤلفون: |
Espinoza, Ingrid, Kurapaty, Chandra, Park, Cheol-Hong, Van der Steen, Travis, Kleer, Celina G., Wiley, Elizabeth, Rademaker, Alfred, Cuyàs, Elisabet, Verdura, Sara, Buxó Pujolràs, Maria, Reynolds, Carol, Menéndez Menéndez, Javier Abel, Lupu, Ruth |
| المصدر: |
American Journal of Cancer Research, 2022, vol. 12, núm. 2, p. 839-851 ; Articles publicats (IdIBGi) ; Espinoza, Ingrid Kurapaty, Chandra Park, Cheol-Hong Van der Steen, Travis Kleer, Celina G. Wiley, Elizabeth Rademaker, Alfred Cuyàs, Elisabet Verdura, Sara Buxó Pujolràs, Maria Reynolds, Carol Menéndez Menéndez, Javier Abel Lupu, Ruth 2022 Depletion of CCN1/CYR61 reduces triple-negative/basal-like breast cancer aggressiveness American Journal Of Cancer Research 12 2 839 851 |
| سنة النشر: |
2022 |
| المجموعة: |
Universitat de Girona: DUGiDocs (UdG Digital Repository) |
| مصطلحات موضوعية: |
Mama -- Càncer -- Tractament, Metàstasi, Breast -- Cancer -- Treatment, Metastasis |
| الوصف: |
Triple-negative/basal-like breast cancer (BC) is characterized by aggressive biological features, which allow relapse and metastatic spread to occur more frequently than in hormone receptor-positive (luminal) subtypes. The molecular complexity of triple-negative/basal-like BC poses major challenges for the implementation of targeted therapies, and chemotherapy remains the standard approach at all stages. The matricellular protein cysteinerich angiogenic inducer 61 (CCN1/CYR61) is associated with aggressive metastatic phenotypes and poor prognosis in BC, but it is unclear whether anti-CCN1 approaches can be successfully applied in triple-negative/basal-like BC. Herein, we first characterized the prevalence of CNN1 expression in matched samples of primary tumors and metastatic relapse in a series of patients with BC. We then investigated the biological effect of CCN1 depletion on tumorigenic traits in vitro and in vivo using archetypal TNBC cell lines. Immunohistochemical analyses of tissue microarrays revealed a significant increase of the highest CCN1 score in recurrent tissues of triple-negative/basallike BC tumors. Stable silencing of CCN1 in triple-negative/basal-like BC cells promoted a marked reduction in the expression of the CCN1 integrin receptor αv β3, inhibited anchorage-dependent cell growth, reduced clonogenicity, and impaired migration capacity. In an orthotopic model of triple-negative/basal-like BC, silencing of CCN1 notably reduced tumor burden, which was accompanied by decreased microvessel density and concurrent induction of the luminal epithelial marker E-cadherin. Thus, CNN1/CYR61-targeting strategies might have therapeutic value in suppressing the biological aggressiveness of triple-negative/basal-like BC ; The authors would like to thank Kenneth McCreath for detailed editing of this manuscript. This work was supported by the NIH National Cancer Institute Grants R01 CA11-8975 and R01 CA116623 (to Ruth Lupu) and by the U.S. Department of Defense (DOD)- Breakthrough 3 Grants BC151072 and BC15- ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
13 p.; application/pdf |
| اللغة: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/issn/2156-6976; http://hdl.handle.net/10256/20801 |
| الاتاحة: |
http://hdl.handle.net/10256/20801 |
| Rights: |
Reconeixement-NoComercial 4.0 Internacional ; http://creativecommons.org/licenses/by-nc/4.0 ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.6A5AD0E8 |
| قاعدة البيانات: |
BASE |