Academic Journal
Normal-Appearing White Matter Deteriorates over the Year After an Ischemic Stroke and Is Associated with Global Cognition
| العنوان: | Normal-Appearing White Matter Deteriorates over the Year After an Ischemic Stroke and Is Associated with Global Cognition |
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| المؤلفون: | Sagnier, Sharmila, Catheline, Gwenaëlle, Dilharreguy, Bixente, Linck, Pierre-Antoine, Coupé, Pierrick, Munsch, Fanny, Bigourdan, Antoine, Poli, Mathilde, Debruxelles, Sabrina, Renou, Pauline, Olindo, Stéphane, Rouanet, François, Dousset, Vincent, Tourdias, Thomas, Sibon, Igor |
| المساهمون: | Institut de Neurosciences cognitives et intégratives d'Aquitaine (INCIA), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1 (UB)-SFR Bordeaux Neurosciences-Centre National de la Recherche Scientifique (CNRS), CHU Bordeaux, Laboratoire Bordelais de Recherche en Informatique (LaBRI), Université de Bordeaux (UB)-École Nationale Supérieure d'Électronique, Informatique et Radiocommunications de Bordeaux (ENSEIRB)-Centre National de la Recherche Scientifique (CNRS), Patch-based processing for medical and natural images (PICTURA), Université de Bordeaux (UB)-École Nationale Supérieure d'Électronique, Informatique et Radiocommunications de Bordeaux (ENSEIRB)-Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB)-École Nationale Supérieure d'Électronique, Informatique et Radiocommunications de Bordeaux (ENSEIRB)-Centre National de la Recherche Scientifique (CNRS), Beth Israel Deaconess Medical Center Boston (BIDMC), Harvard Medical School Boston (HMS), Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale (U1215 Inserm - UB), Université de Bordeaux (UB)-Institut François Magendie-Institut National de la Santé et de la Recherche Médicale (INSERM), ANR-10-LABX-0057,TRAIL,Translational Research and Advanced Imaging Laboratory(2010) |
| المصدر: | ISSN: 1868-4483 ; Translational stroke research./Transl Stroke Res ; https://hal.science/hal-03651487 ; Translational stroke research./Transl Stroke Res, 2022, ⟨10.1007/s12975-022-00988-8⟩. |
| بيانات النشر: | HAL CCSD Springer |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Diffusion tensor imaging, Longitudinal, Prognosis, Stroke, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging |
| الوصف: | International audience ; Normal-appearing white matter (NAWM) is a hub of plasticity, but data relating to its influence on post-ischemic stroke (IS) outcome remain scarce. The aim of this study was to evaluate the relationship between NAWM integrity and cognitive outcome after an IS. A longitudinal study was conducted including supra-tentorial IS patients. A 3-Tesla brain MRI was performed at baseline and 1 year, allowing the analyses of mean fractional anisotropy (FA) and mean diffusivity (MD) in NAWM masks, along with the volume of white matter hyperintensities (WMH) and IS. A Montreal Cognitive Assessment (MoCA), an Isaacs set test, and a Zazzo's cancellation task were performed at baseline, 3 months and 1 year. Mixed models were built, followed by Tract-based Spatial Statistics (TBSS) analyses. Ninety-five patients were included in the analyses (38% women, median age 69 ± 20). FA significantly decreased, and MD significantly increased between baseline and 1 year, while cognitive scores improved. Patients who decreased their NAWM FA more over the year had a slower cognitive improvement on MoCA (β = - 0.11, p = 0.05). The TBSS analyses showed that patients who presented the highest decrease of FA in various tracts of white matter less improved their MoCA performances, regardless of WMH and IS volumes, demographic confounders, and clinical severity. NAWM integrity deteriorates over the year after an IS, and is associated with a cognitive recovery slowdown. The diffusion changes recorded here in patients starting with an early preserved white matter structure could have long term impact on cognition. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/35106712; PUBMED: 35106712 |
| DOI: | 10.1007/s12975-022-00988-8 |
| الاتاحة: | https://hal.science/hal-03651487 https://hal.science/hal-03651487v1/document https://hal.science/hal-03651487v1/file/Sagnier_et_al-2022-Translational_Stroke_Research.pdf https://doi.org/10.1007/s12975-022-00988-8 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.6A272008 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s12975-022-00988-8 |
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