Academic Journal
Analysis of Relationships between Metabolic Changes and Selected Nutrient Intake in Women Environmentally Exposed to Arsenic
| العنوان: | Analysis of Relationships between Metabolic Changes and Selected Nutrient Intake in Women Environmentally Exposed to Arsenic |
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| المؤلفون: | Monika Sijko-Szpańska, Lucyna Kozłowska |
| المصدر: | Metabolites, Vol 14, Iss 1, p 75 (2024) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2024 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | inorganic arsenic, metabolic pathways, diet, untargeted metabolomic, metabolism, exposure, Microbiology, QR1-502 |
| الوصف: | Nutrients involved in the metabolism of inorganic arsenic (iAs) may play a crucial role in mitigating the adverse health effects associated with such exposure. Consequently, the objective of this study was to analyze the association between the intake levels of nutrients involved in iAs metabolism and alterations in the metabolic profile during arsenic exposure. The study cohort comprised environmentally exposed women: WL (lower total urinary arsenic (As), n = 73) and WH (higher As, n = 73). The analysis included urinary untargeted metabolomics (conducted via liquid chromatography–mass spectrometry) and the assessment of nutrient intake involved in iAs metabolism, specifically methionine, vitamins B 2 , B 6 , and B 12 , folate, and zinc (based on 3-day dietary records of food and beverages). In the WL group, the intake of all analyzed nutrients exhibited a negative correlation with 5 metabolites (argininosuccinic acid, 5-hydroxy-L-tryptophan, 11-trans-LTE4, mevalonic acid, aminoadipic acid), while in the WH group, it correlated with 10 metabolites (5-hydroxy-L-tryptophan, dihyroxy-1H-indole glucuronide I, 11-trans-LTE4, isovalerylglucuronide, 18-oxocortisol, 3-hydroxydecanedioic acid, S-3-oxodecanoyl cysteamine, L-arginine, p-cresol glucuronide, thromboxane B2). Furthermore, nutrient intake demonstrated a positive association with 3 metabolites in the WL group (inosine, deoxyuridine, glutamine) and the WH group (inosine, N-acetyl-L-aspartic acid, tetrahydrodeoxycorticosterone). Altering the intake of nutrients involved in iAs metabolism could be a pivotal factor in reducing the negative impact of arsenic exposure on the human body. This study underscores the significance of maintaining adequate nutrient intake, particularly in populations exposed to arsenic. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2218-1989 |
| Relation: | https://www.mdpi.com/2218-1989/14/1/75; https://doaj.org/toc/2218-1989; https://doaj.org/article/0ce50a09f0d94b2a9d0b55750e4b9573 |
| DOI: | 10.3390/metabo14010075 |
| الاتاحة: | https://doi.org/10.3390/metabo14010075 https://doaj.org/article/0ce50a09f0d94b2a9d0b55750e4b9573 |
| رقم الانضمام: | edsbas.6A1C23E4 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 22181989 |
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| DOI: | 10.3390/metabo14010075 |