Academic Journal
Melatonin attenuates scopolamine‐induced cognitive dysfunction through SIRT1/IRE1α/XBP1 pathway
| العنوان: | Melatonin attenuates scopolamine‐induced cognitive dysfunction through SIRT1/IRE1α/XBP1 pathway |
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| المؤلفون: | Liu, Xiao‐Qi, Huang, Shun, Zheng, Jia‐Yi, Wan, Can, Hu, Tian, Cai, Ye‐Feng, Wang, Qi, Zhang, Shi‐Jie |
| المساهمون: | National Natural Science Foundation of China, Basic and Applied Basic Research Foundation of Guangdong Province |
| المصدر: | CNS Neuroscience & Therapeutics ; volume 30, issue 7 ; ISSN 1755-5930 1755-5949 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2024 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Background The prevalence of dementia around the world is increasing, and these patients are more likely to have cognitive impairments, mood and anxiety disorders (depression, anxiety, and panic disorder), and attention deficit disorders over their lifetime. Previous studies have proven that melatonin could improve memory loss, but its specific mechanism is still confused. Methods In this study, we used in vivo and in vitro models to examine the neuroprotective effect of melatonin on scopolamine (SCOP)‐induced cognitive dysfunction. The behavioral tests were performed. 18 F‐FDG PET imaging was used to assess the metabolism of the brain. Protein expressions were determined through kit detection, Western blot, and immunofluorescence. Nissl staining was conducted to reflect neurodegeneration. MTT assay and RNAi transfection were applied to perform the in vitro experiments. Results We found that melatonin could ameliorate SCOP‐induced cognitive dysfunction and relieve anxious‐like behaviors or HT22 cell damage. 18 F‐FDG PET‐CT results showed that melatonin could improve cerebral glucose uptake in SCOP‐treated mice. Melatonin restored the cholinergic function, increased the expressions of neurotrophic factors, and ameliorated oxidative stress in the brain of SCOP‐treated mice. In addition, melatonin upregulated the expression of silent information regulator 1 (SIRT1), which further relieved endoplasmic reticulum (ER) stress by decreasing the expression of phosphorylate inositol‐requiring enzyme (p‐IRE1α) and its downstream, X‐box binding protein 1 (XBP1). Conclusions These results indicated that melatonin could ameliorate SCOP‐induced cognitive dysfunction through the SIRT1/IRE1α/XBP1 pathway. SIRT1 might be the critical target of melatonin in the treatment of dementia. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/cns.14891 |
| الاتاحة: | http://dx.doi.org/10.1111/cns.14891 https://onlinelibrary.wiley.com/doi/pdf/10.1111/cns.14891 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.6A15381E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/cns.14891 |
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