التفاصيل البيبلوغرافية
| العنوان: |
Toll-like receptor expression in the nervous system of bovine alpha-herpesvirus-infected calves |
| المؤلفون: |
Marin, Maia Solange, Quintana, Silvina, Leunda, Maria Rosa, Odeón, Anselmo Carlos, Perez, Sandra |
| بيانات النشر: |
Elsevier |
| المجموعة: |
CONICET Digital (Consejo Nacional de Investigaciones Científicas y Técnicas) |
| مصطلحات موضوعية: |
Toll-Like Receptors, Bovine Herpesviruses, Expression Patterns, Encephalitis, https://purl.org/becyt/ford/4.3, https://purl.org/becyt/ford/4 |
| الوصف: |
In this study, the expression levels of viral Toll-like receptors (TLRs) in the nervous system of bovine herpesvirus type 5 (BoHV-5)-infected calves were investigated. A significant increase in the expression of TLRs 3 and 7–9 was found in the anterior cerebral cortex during acute infection and viral reactivation. In the trigeminal ganglia, only TLR9 expression was significantly affected. The magnitude of the increase was lower in BoHV-1-infected calves, suggesting that a restricted immune response might protect against exacerbated inflammatory responses in the brain. This work describes, for the first time, the involvement of TLRs 3 and 7–9 in the recognition of BoHV in the bovine nervous system, indicating that the expression of these receptors might be associated with the development of neurological disease. Modulation of the signalling pathways mediated by TLRs might provide an effective approach to control the neuro-immune response to BoHV-5, which may be responsible for neurological lesions. ; Fil: Marin, Maia Solange. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina ; Fil: Quintana, Silvina. Instituto de Análisis Fares Taie; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina ; Fil: Leunda, Maria Rosa. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Sur. Estación Experimental Agropecuaria Balcarce; Argentina ; Fil: Odeón, Anselmo Carlos. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Sur. Estación Experimental Agropecuaria Balcarce; Argentina ; Fil: Perez, Sandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| تدمد: |
0034-5288 |
| Relation: |
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0034528814001866; http://hdl.handle.net/11336/33616; Marin, Maia Solange; Leunda, Maria Rosa; Odeón, Anselmo Carlos; Perez, Sandra; Quintana, Silvina; Toll-like receptor expression in the nervous system of bovine alpha-herpesvirus-infected calves; Elsevier; Research in Veterinary Science; 97; 2; 7-2014; 422-429; CONICET Digital; CONICET |
| الاتاحة: |
http://hdl.handle.net/11336/33616 |
| Rights: |
info:eu-repo/semantics/openAccess ; https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
| رقم الانضمام: |
edsbas.6A0CCFD4 |
| قاعدة البيانات: |
BASE |