التفاصيل البيبلوغرافية
| العنوان: |
Association of Maternal and Child Anemia With Brain Structure in Early Life in South Africa |
| المؤلفون: |
Wedderburn, Catherine J., Ringshaw, Jessica E., Donald, Kirsten A., Joshi, Shantanu H., Subramoney, Sivenesi, Fouche, Jean-Paul, Stadler, Jacob A. M., Barnett, Whitney, Rehman, Andrea M., Hoffman, Nadia, Roos, Annerine, Narr, Katherine L., Zar, Heather J., Stein, Dan J. |
| المصدر: |
JAMA Netw Open |
| بيانات النشر: |
American Medical Association |
| سنة النشر: |
2022 |
| مصطلحات موضوعية: |
Original Investigation, demo, socio |
| الوصف: |
IMPORTANCE: Anemia affects millions of pregnant women and their children worldwide, particularly in low- and middle-income countries. Although anemia in pregnancy is a well-described risk factor for cognitive development, the association with child brain structure is poorly understood. OBJECTIVE: To explore the association of anemia during pregnancy and postnatal child anemia with brain structure in early life. DESIGN, SETTING, AND PARTICIPANTS: This neuroimaging nested cohort study was embedded within the Drakenstein Child Health Study (DCHS), a population-based birth cohort in South Africa. Pregnant individuals were enrolled into the DCHS between 2012 and 2015 from 2 clinics in a periurban setting. Mother-child pairs were assessed prospectively; follow-up is ongoing. A subgroup of children had brain magnetic resonance imaging (MRI) at age 2 to 3 years from 2015 to 2018. This study focused on the 147 pairs with structural neuroimaging and available hemoglobin data. Data analyses were conducted in 2021 and 2022. EXPOSURES: Mothers had hemoglobin measurements during pregnancy, and a subgroup of children had hemoglobin measurements during early life. Anemia was classified as hemoglobin levels less than 11 g/dL based on World Health Organization guidelines; children younger than 6 months were classified using local guidelines. MAIN OUTCOMES AND MEASURES: Child brain volumes of global, subcortical, and corpus callosum structures were quantified using T1-weighted MRI. Linear regression models were used to analyze the associations between maternal and child anemia with child brain volumes, accounting for potential confounders. RESULTS: Of 147 children (mean [SD] age at MRI, 34 [2] months; 83 [56.5%] male) with high-resolution MRI scans, prevalence of maternal anemia in pregnancy was 31.3% (46 of 147; median [IQR] gestation of measurement: 13 [9-20] weeks). Maternal anemia during pregnancy was significantly associated with smaller volumes of the child caudate bilaterally (adjusted percentage difference, −5.30% [95% CI, ... |
| نوع الوثيقة: |
text |
| اللغة: |
English |
| Relation: |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9719049/ |
| الاتاحة: |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9719049/ |
| Rights: |
undefined |
| رقم الانضمام: |
edsbas.6A08AEB7 |
| قاعدة البيانات: |
BASE |